Prolia and Herniated nucleus pulposus (slipped disk) - a phase IV clinical study of FDA data

Summary:

Herniated nucleus pulposus (slipped disk) is reported as a side effect among people who take Prolia (denosumab), especially for people who are female, 60+ old, have been taking the drug for 1 - 2 years also take Fosamax, and have Osteopenia.

The phase IV clinical study analyzes which people have Herniated nucleus pulposus (slipped disk) when taking Prolia. It is created by eHealthMe based on reports of 150,727 people who have side effects when taking Prolia from the FDA, and is updated regularly.

What is Prolia?

Prolia has active ingredients of denosumab. It is often used in osteoporosis. eHealthMe is studying from 151,389 Prolia users. Check the latest studies of Prolia.

What is Herniated nucleus pulposus (slipped disk)?

Herniated nucleus pulposus (slipped disk) is found to be associated with 582 drugs and 909 conditions by eHealthMe. Check the latest studies of Herniated nucleus pulposus (slipped disk).

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

150,727 people reported to have side effects when taking Prolia.
Among them, 27 people (0.02%) have Herniated nucleus pulposus (slipped disk).

Could Prolia cause Herniated nucleus pulposus (slipped disk)?

Among these 27 people:

How long have people been on Prolia when they have Herniated nucleus pulposus (slipped disk)? *

What is the gender of people who have Herniated nucleus pulposus (slipped disk) when taking Prolia? *

female: 92.59 %
male: 7.41 %

What is the age of people who have Herniated nucleus pulposus (slipped disk) when taking Prolia? *

What are other drugs people take besides Prolia? *

What are other side effects people have besides Herniated nucleus pulposus (slipped disk)? *

Back Pain: 9 people, 33.33%
Rickets (softening of bones): 9 people, 33.33%
Joint Pain: 7 people, 25.93%
Urinary Tract Infection: 6 people, 22.22%
Pain In Extremity: 6 people, 22.22%
High Blood Pressure: 6 people, 22.22%
Drug Ineffective: 5 people, 18.52%
Bone Pain: 5 people, 18.52%
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve): 5 people, 18.52%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 5 people, 18.52%

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 11.11%
Osteopenia (a condition where bone mineral density is lower than normal): 3 people, 11.11%
Bone Loss: 2 people, 7.41%
Stress And Anxiety: 2 people, 7.41%
Muscle Spasms (muscle contraction): 2 people, 7.41%
Thyroid Diseases: 2 people, 7.41%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 7.41%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 7.41%
Paget's Disease (disorder that involves abnormal bone destruction and regrowth, which results in deformity): 1 person, 3.70%
Neuropathy Peripheral (surface nerve damage): 1 person, 3.70%

* Approximation only. Some reports may have incomplete information.

Do you take Prolia and have Herniated nucleus pulposus (slipped disk)?

- Check whether Herniated nucleus pulposus (slipped disk) is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Prolia:

Prolia (151,389 reports)

Herniated nucleus pulposus (slipped disk) treatments and more:

Herniated nucleus pulposus (slipped disk) (5,608 reports)

How severe was Herniated nucleus pulposus (slipped disk) and when was it recovered:

Herniated nucleus pulposus (slipped disk) in Prolia

Expand to all the drugs that have ingredients of denosumab:

Herniated nucleus pulposus (slipped disk) and drugs with ingredients of denosumab (35 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Prolia:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Herniated nucleus pulposus (slipped disk):

Herniated nucleus pulposus (slipped disk) (582 drugs)

Browse all the conditions that are associated with Herniated nucleus pulposus (slipped disk):

Herniated nucleus pulposus (slipped disk) (909 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on denosumab (the active ingredients of Prolia) and Prolia (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.