Prolia and Obtundation - a phase IV clinical study of FDA data

Summary:

Obtundation is reported as a side effect among people who take Prolia (denosumab), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Sandostatin, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Obtundation when taking Prolia. It is created by eHealthMe based on reports of 150,727 people who have side effects when taking Prolia from the FDA, and is updated regularly.

What is Prolia?

Prolia has active ingredients of denosumab. It is often used in osteoporosis. eHealthMe is studying from 151,385 Prolia users. Check the latest studies of Prolia.

What is Obtundation?

Obtundation (less than full mental capacity in a medical patient, typically as a result of a medical condition or trauma) is found to be associated with 2,353 drugs and 3,193 conditions by eHealthMe. Check the latest studies of Obtundation.

On Jan, 14, 2026

150,727 people reported to have side effects when taking Prolia.
Among them, 58 people (0.04%) have Obtundation.

Among these 58 people:

* Approximation only. Some reports may have incomplete information.

Do you take Prolia and have Obtundation?

- Check whether Obtundation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Prolia:

Prolia (151,385 reports)

Obtundation treatments and more:

Obtundation (57,420 reports)

How severe was Obtundation and when was it recovered:

Obtundation in Prolia

Expand to all the drugs that have ingredients of denosumab:

Obtundation and drugs with ingredients of denosumab (88 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Prolia:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Obtundation:

Obtundation (2,353 drugs)

Browse all the conditions that are associated with Obtundation:

Obtundation (3,193 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on denosumab (the active ingredients of Prolia) and Prolia (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.