Promethazine w/ codeine and Hyperhidrosis - a phase IV clinical study of FDA data

Summary:

Hyperhidrosis is reported as a side effect among people who take Promethazine w/ codeine (codeine phosphate; promethazine hydrochloride), especially for people who are female, 40-49 old, have been taking the drug for 1 - 6 months also take Albuterol, and have Bronchitis.

The phase IV clinical study analyzes which people have Hyperhidrosis when taking Promethazine w/ codeine. It is created by eHealthMe based on reports of 259 people who have side effects when taking Promethazine w/ codeine from the FDA, and is updated regularly.

What is Promethazine w/ codeine?

Promethazine w/ codeine has active ingredients of codeine phosphate; promethazine hydrochloride. It is often used in cough. eHealthMe is studying from 279 Promethazine w/ codeine users. Check the latest studies of Promethazine w/ codeine.

What is Hyperhidrosis?

Hyperhidrosis (abnormally increased sweating) is found to be associated with 2,552 drugs and 3,546 conditions by eHealthMe. Check the latest studies of Hyperhidrosis.

On Jul, 07, 2026

259 people reported to have side effects when taking Promethazine w/ codeine.
Among them, 30 people (11.58%) have Hyperhidrosis.

Could Promethazine w/ codeine cause Hyperhidrosis?

Among these 30 people:

How long have people been on Promethazine w/ codeine when they have Hyperhidrosis? *

What is the gender of people who have Hyperhidrosis when taking Promethazine w/ codeine? *

female: 53.33 %
male: 46.67 %

What is the age of people who have Hyperhidrosis when taking Promethazine w/ codeine? *

What are other drugs people take besides Promethazine w/ codeine? *

What are other side effects people have besides Hyperhidrosis? *

Nausea (feeling of having an urge to vomit): 30 people, 100.00%
Nausea And Vomiting: 23 people, 76.67%
Abdominal Discomfort: 21 people, 70.00%
Back Pain: 21 people, 70.00%
Weakness: 17 people, 56.67%
Abdominal Pain: 16 people, 53.33%
Constipation: 14 people, 46.67%
Jaundice - Yellow Skin (a yellowish pigmentation of the skin): 14 people, 46.67%
Oedema Peripheral (superficial swelling): 14 people, 46.67%
Hepatitis (inflammation of the liver): 14 people, 46.67%

What are the existing conditions these people have? *

Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 15 people, 50.00%
Stress And Anxiety: 9 people, 30.00%
Depression: 7 people, 23.33%
Bipolar Disorder (mood disorder): 7 people, 23.33%
Sleep Disorder: 6 people, 20.00%
Idiopathic Thrombocytopenic Purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting): 6 people, 20.00%
Anger: 5 people, 16.67%
Insomnia (sleeplessness): 2 people, 6.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 6.67%
Gastric Ph Decreased: 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Promethazine w/ codeine and have Hyperhidrosis?

- Check whether Hyperhidrosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Promethazine w/ codeine:

Promethazine w/ codeine (279 reports)

Hyperhidrosis treatments and more:

Hyperhidrosis (147,206 reports)

How severe was Hyperhidrosis and when was it recovered:

Hyperhidrosis in Promethazine w/ codeine

Expand to all the drugs that have ingredients of codeine phosphate; promethazine hydrochloride:

Hyperhidrosis and drugs with ingredients of codeine phosphate; promethazine hydrochloride (56 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Promethazine w/ codeine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperhidrosis:

Hyperhidrosis (2,552 drugs)

Browse all the conditions that are associated with Hyperhidrosis:

Hyperhidrosis (3,546 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on codeine phosphate; promethazine hydrochloride (the active ingredients of Promethazine w/ codeine) and Promethazine w/ codeine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.