Promethazine w/ codeine and Oedema peripheral - a phase IV clinical study of FDA data

Summary:

Oedema peripheral is reported as a side effect among people who take Promethazine w/ codeine (codeine phosphate; promethazine hydrochloride), especially for people who are male, 50-59 old, have been taking the drug for < 1 month also take Albuterol, and have Bronchitis.

The phase IV clinical study analyzes which people have Oedema peripheral when taking Promethazine w/ codeine. It is created by eHealthMe based on reports of 259 people who have side effects when taking Promethazine w/ codeine from the FDA, and is updated regularly.

What is Promethazine w/ codeine?

Promethazine w/ codeine has active ingredients of codeine phosphate; promethazine hydrochloride. It is often used in cough. eHealthMe is studying from 279 Promethazine w/ codeine users. Check the latest studies of Promethazine w/ codeine.

What is Oedema peripheral?

Oedema peripheral (superficial swelling) is found to be associated with 2,772 drugs and 3,465 conditions by eHealthMe. Check the latest studies of Oedema peripheral.

On Jul, 07, 2026

259 people reported to have side effects when taking Promethazine w/ codeine.
Among them, 39 people (15.06%) have Oedema peripheral.

Could Promethazine w/ codeine cause Oedema peripheral?

Among these 39 people:

How long have people been on Promethazine w/ codeine when they have Oedema peripheral? *

What is the gender of people who have Oedema peripheral when taking Promethazine w/ codeine? *

female: 38.46 %
male: 61.54 %

What is the age of people who have Oedema peripheral when taking Promethazine w/ codeine? *

What are other drugs people take besides Promethazine w/ codeine? *

What are other side effects people have besides Oedema peripheral? *

Back Pain: 28 people, 71.79%
Fatigue (feeling of tiredness): 19 people, 48.72%
Joint Pain: 17 people, 43.59%
Gait Disturbance: 16 people, 41.03%
Constipation: 16 people, 41.03%
Ascites (accumulation of fluid in the abdominal cavity): 15 people, 38.46%
Nausea (feeling of having an urge to vomit): 15 people, 38.46%
Abdominal Pain: 15 people, 38.46%
Nausea And Vomiting: 15 people, 38.46%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 15 people, 38.46%

What are the existing conditions these people have? *

Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 17 people, 43.59%
Pain: 15 people, 38.46%
Metastases To Bone (cancer spreads to bone): 10 people, 25.64%
Mixed Incontinence (a combination of stress and urge incontinence): 5 people, 12.82%
Allergic Rhinitis: 5 people, 12.82%
Depression: 5 people, 12.82%
Fibromyalgia (a long-term condition which causes pain all over the body): 5 people, 12.82%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 12.82%
High Blood Pressure: 5 people, 12.82%
Hypertriglyceridaemia (excess of triglycerides in the blood): 5 people, 12.82%

* Approximation only. Some reports may have incomplete information.

Do you take Promethazine w/ codeine and have Oedema peripheral?

- Check whether Oedema peripheral is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Promethazine w/ codeine:

Promethazine w/ codeine (279 reports)

Oedema peripheral treatments and more:

Oedema peripheral (172,690 reports)

How severe was Oedema peripheral and when was it recovered:

Oedema peripheral in Promethazine w/ codeine

Expand to all the drugs that have ingredients of codeine phosphate; promethazine hydrochloride:

Oedema peripheral and drugs with ingredients of codeine phosphate; promethazine hydrochloride

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Promethazine w/ codeine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Oedema peripheral:

Oedema peripheral (2,772 drugs)

Browse all the conditions that are associated with Oedema peripheral:

Oedema peripheral (3,465 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on codeine phosphate; promethazine hydrochloride (the active ingredients of Promethazine w/ codeine) and Promethazine w/ codeine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.