Prometrium and Sleep disorder - a phase IV clinical study of FDA data

Summary:

Sleep disorder is reported as a side effect among people who take Prometrium (progesterone), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Xeljanz, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Sleep disorder when taking Prometrium. It is created by eHealthMe based on reports of 5,562 people who have side effects when taking Prometrium from the FDA, and is updated regularly.

What is Prometrium?

Prometrium has active ingredients of progesterone. It is often used in menopause. eHealthMe is studying from 5,980 Prometrium users. Check the latest studies of Prometrium.

What is Sleep disorder?

Sleep disorder is found to be associated with 2,101 drugs and 2,940 conditions by eHealthMe. Check the latest studies of Sleep disorder.

On Jul, 31, 2026

5,562 people reported to have side effects when taking Prometrium.
Among them, 26 people (0.47%) have Sleep disorder.

Among these 26 people:

How long have people been on Prometrium when they have Sleep disorder? *

What is the gender of people who have Sleep disorder when taking Prometrium? *

female: 100 %
male: 0.0 %

What is the age of people who have Sleep disorder when taking Prometrium? *

What are other drugs people take besides Prometrium? *

What are other side effects people have besides Sleep disorder? *

Fatigue (feeling of tiredness): 10 people, 38.46%
Drug Ineffective: 7 people, 26.92%
Diarrhea: 6 people, 23.08%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 6 people, 23.08%
Joint Pain: 5 people, 19.23%
Pain: 5 people, 19.23%
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder): 4 people, 15.38%
Itching: 4 people, 15.38%
Joint Swelling: 4 people, 15.38%
Musculoskeletal Stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 4 people, 15.38%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 11.54%
Migraine (headache): 2 people, 7.69%
Malignant Melanoma (skin cancer rises from melancytes): 2 people, 7.69%
Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 1 person, 3.85%
Generalized Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry): 1 person, 3.85%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 3.85%
Constipation: 1 person, 3.85%
Depression: 1 person, 3.85%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 1 person, 3.85%
Drowsiness: 1 person, 3.85%

* Approximation only. Some reports may have incomplete information.

Do you take Prometrium and have Sleep disorder?

- Check whether Sleep disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Prometrium:

Prometrium (5,980 reports)

Sleep disorder treatments and more:

Sleep disorder (167,338 reports)

Browse all side effects of Prometrium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sleep disorder:

Sleep disorder (2,101 drugs)

Browse all the conditions that are associated with Sleep disorder:

Sleep disorder (2,940 conditions)

Related publications that referenced our studies

Lin SC, Su YC, Huang YS, Lee CC, "Zolpidem increased cancer risk in patients with sleep disorder: A 3-year follow-up study", Journal of Medical Sciences, 2016 Mar .
Lin SC, Su YC, Huang YS, Lee CC, "Zolpidem increased cancer risk in patients with sleep disorder: A 3-year follow-up study", Journal of Medical Sciences, 2016 Mar .

How the study uses the data?

The study uses data from the FDA. It is based on progesterone (the active ingredients of Prometrium) and Prometrium (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.