Propafenone hydrochloride and Constipation - a phase IV clinical study of FDA data

Summary:

Constipation is reported as a side effect among people who take Propafenone hydrochloride (propafenone hydrochloride), especially for people who are male, 60+ old, have been taking the drug for 2 - 5 years also take Lipitor, and have Crohn's disease.

The phase IV clinical study analyzes which people have Constipation when taking Propafenone hydrochloride. It is created by eHealthMe based on reports of 1,202 people who have side effects when taking Propafenone hydrochloride from the FDA, and is updated regularly.

What is Propafenone hydrochloride?

Propafenone hydrochloride has active ingredients of propafenone hydrochloride. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 1,397 Propafenone hydrochloride users. Check the latest studies of Propafenone hydrochloride.

What is Constipation?

Constipation is found to be associated with 3,004 drugs and 4,618 conditions by eHealthMe. Check the latest studies of Constipation.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 13, 2026

1,202 people reported to have side effects when taking Propafenone hydrochloride.
Among them, 20 people (1.66%) have Constipation.

Could Propafenone hydrochloride cause Constipation?

Among these 20 people:

How long have people been on Propafenone hydrochloride when they have Constipation? *

What is the gender of people who have Constipation when taking Propafenone hydrochloride? *

female: 38.89 %
male: 61.11 %

What is the age of people who have Constipation when taking Propafenone hydrochloride? *

What are other drugs people take besides Propafenone hydrochloride? *

What are other side effects people have besides Constipation? *

Drug Ineffective: 8 people, 40.00%
Chest Pain: 7 people, 35.00%
Malaise (a feeling of general discomfort or uneasiness): 5 people, 25.00%
Joint Pain: 5 people, 25.00%
Dizziness: 5 people, 25.00%
Dyspnea (difficult or laboured breathing): 5 people, 25.00%
Skin Blushing/flushing (a sudden reddening of the face, neck): 5 people, 25.00%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 5 people, 25.00%
Weakness: 4 people, 20.00%
Hypoaesthesia (reduced sense of touch or sensation): 4 people, 20.00%

What are the existing conditions these people have? *

Diabetes: 2 people, 10.00%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 2 people, 10.00%
Skin Cancer: 1 person, 5.00%
Quit Smoking: 1 person, 5.00%
Osteoporosis (bones weak and more likely to break): 1 person, 5.00%
Multiple Myeloma (cancer of the plasma cells): 1 person, 5.00%
High Blood Pressure: 1 person, 5.00%
High Blood Cholesterol: 1 person, 5.00%
Hepatitis C Antibody Positive: 1 person, 5.00%
Disease Recurrence: 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Propafenone hydrochloride and have Constipation?

- Check whether Constipation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Propafenone hydrochloride:

Propafenone hydrochloride (1,397 reports)

Constipation treatments and more:

Constipation (337,880 reports)

Browse all side effects of Propafenone hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Constipation:

Constipation (3,004 drugs)

Browse all the conditions that are associated with Constipation:

Constipation (4,618 conditions)

Related publications that referenced our studies

Tesic D, Kostic M, Paunovic D, Jankovic SM, "Analysis of the cost–effectiveness of dronedarone versus amiodarone, propafenone, and sotalol in patients with atrial fibrillation: results for Serbia", Kardiologia Polska (Polish Heart Journal), 2016 Jan .
Tesic D, Kostic M, Paunovic D, Jankovic SM, "Analysis of the cost–effectiveness of dronedarone versus amiodarone, propafenone, and sotalol in patients with atrial fibrillation: results for Serbia", Kardiologia Polska (Polish Heart Journal), 2016 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on propafenone hydrochloride (the active ingredients of Propafenone hydrochloride) and Propafenone hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.