Protonix and Androgen deficiency - a phase IV clinical study of FDA data

Summary:

Androgen deficiency is reported as a side effect among people who take Protonix (pantoprazole sodium), especially for people who are 60+ old, have been taking the drug for 5 - 10 years also take Nexium, and have Indigestion.

The phase IV clinical study analyzes which people have Androgen deficiency when taking Protonix. It is created by eHealthMe based on reports of 130,073 people who have side effects when taking Protonix from the FDA, and is updated regularly.

What is Protonix?

Protonix has active ingredients of pantoprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 132,658 Protonix users. Check the latest studies of Protonix.

What is Androgen deficiency?

Androgen deficiency is found to be associated with 98 drugs and 231 conditions by eHealthMe. Check the latest studies of Androgen deficiency.



On Jul, 26, 2026

130,073 people reported to have side effects when taking Protonix.
Among them, 19 people (0.01%) have Androgen deficiency.

Could Protonix cause Androgen deficiency?

Among these 19 people:

How long have people been on Protonix when they have Androgen deficiency? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 33.33 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 33.33 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 33.33 %
  • 10+ years: 0.0 %

What is the age of people who have Androgen deficiency when taking Protonix? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 14.29 %
  • 30-39: 14.29 %
  • 40-49: 7.14 %
  • 50-59: 7.14 %
  • 60+: 57.14 %

What are other drugs people take besides Protonix? *

  1. Nexium: 13 people, 68.42%
  2. Lasix: 8 people, 42.11%
  3. Prilosec: 8 people, 42.11%
  4. Plavix: 8 people, 42.11%
  5. Oxycodone: 7 people, 36.84%
  6. Prevacid: 7 people, 36.84%
  7. Singulair: 6 people, 31.58%
  8. Simvastatin: 5 people, 26.32%
  9. Pantoprazole: 5 people, 26.32%
  10. Xtandi: 5 people, 26.32%

What are other side effects people have besides Androgen deficiency? *

  1. Osteoporosis (bones weak and more likely to break): 13 people, 68.42%
  2. Bone Disorder: 10 people, 52.63%
  3. Arthritis (form of joint disorder that involves inflammation of one or more joints): 9 people, 47.37%
  4. Fall: 8 people, 42.11%
  5. Weakness: 6 people, 31.58%
  6. Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall): 6 people, 31.58%
  7. Peripheral Swelling: 5 people, 26.32%
  8. Depression: 5 people, 26.32%
  9. The Flu (the flu is caused by an influenza virus): 5 people, 26.32%
  10. Multiple Fractures: 5 people, 26.32%

What are the existing conditions these people have? *

  1. Indigestion: 4 people, 21.05%
  2. Prostate Cancer: 3 people, 15.79%
  3. High Blood Pressure: 3 people, 15.79%
  4. Pain: 3 people, 15.79%
  5. Stress And Anxiety: 2 people, 10.53%
  6. Blood Pressure Abnormal: 2 people, 10.53%
  7. Gastric Disorder (disease of stomach): 2 people, 10.53%
  8. Sleep Disorder: 2 people, 10.53%
  9. High Blood Cholesterol: 2 people, 10.53%
  10. Nervous System Disorder (a general class of medical conditions affecting the nervous system): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Protonix and have Androgen deficiency?

- Check whether Androgen deficiency is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, long term effects of, and alternative drugs to Protonix:

Androgen deficiency treatments and more:

How severe was Androgen deficiency and when was it recovered:

Expand to all the drugs that have ingredients of pantoprazole sodium:

Sub-studies by age:

0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Protonix:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Androgen deficiency:

Browse all the conditions that are associated with Androgen deficiency:


How the study uses the data?

The study uses data from the FDA. It is based on pantoprazole sodium (the active ingredients of Protonix) and Protonix (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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