Protonix and Hypercalcaemia of malignancy - a phase IV clinical study of FDA data

Summary:

Hypercalcaemia of malignancy is reported as a side effect among people who take Protonix (pantoprazole sodium), especially for people who are male, 40-49 old, also take Decadron, and have Metastases to bone.

The phase IV clinical study analyzes which people have Hypercalcaemia of malignancy when taking Protonix. It is created by eHealthMe based on reports of 130,073 people who have side effects when taking Protonix from the FDA, and is updated regularly.

What is Protonix?

Protonix has active ingredients of pantoprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 132,659 Protonix users. Check the latest studies of Protonix.

What is Hypercalcaemia of malignancy?

Hypercalcaemia of malignancy (elevated calcium (ca+) level in the blood with cancer) is found to be associated with 85 drugs and 112 conditions by eHealthMe. Check the latest studies of Hypercalcaemia of malignancy.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

130,073 people reported to have side effects when taking Protonix.
Among them, 13 people (0.01%) have Hypercalcaemia of malignancy.

Could Protonix cause Hypercalcaemia of malignancy?

Among these 13 people:

What is the gender of people who have Hypercalcaemia of malignancy when taking Protonix? *

female: 33.33 %
male: 66.67 %

What is the age of people who have Hypercalcaemia of malignancy when taking Protonix? *

What are other drugs people take besides Protonix? *

What are other side effects people have besides Hypercalcaemia of malignancy? *

General Physical Health Deterioration (weak health status): 10 people, 76.92%
Nausea (feeling of having an urge to vomit): 9 people, 69.23%
Weakness: 9 people, 69.23%
Swallowing Difficulty: 9 people, 69.23%
Fatigue (feeling of tiredness): 9 people, 69.23%
Fall: 9 people, 69.23%
Hypotension (abnormally low blood pressure): 8 people, 61.54%
Nausea And Vomiting: 8 people, 61.54%
Sepsis (a severe blood infection that can lead to organ failure and death): 8 people, 61.54%
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 7 people, 53.85%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 6 people, 46.15%
Metastases To Bone (cancer spreads to bone): 6 people, 46.15%
Cancer Pain: 3 people, 23.08%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 15.38%
Stress And Anxiety: 1 person, 7.69%
Pain In Jaw: 1 person, 7.69%
Pain: 1 person, 7.69%
Oesophageal Carcinoma (cancer tumour of oesophagus): 1 person, 7.69%
Neuropathy Peripheral (surface nerve damage): 1 person, 7.69%
Nausea (feeling of having an urge to vomit): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Protonix and have Hypercalcaemia of malignancy?

- Check whether Hypercalcaemia of malignancy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Protonix:

Protonix (132,659 reports)

Browse all side effects of Protonix:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypercalcaemia of malignancy:

Hypercalcaemia of malignancy (85 drugs)

Browse all the conditions that are associated with Hypercalcaemia of malignancy:

Hypercalcaemia of malignancy (112 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on pantoprazole sodium (the active ingredients of Protonix) and Protonix (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.