Protonix and Large intestinal obstruction - a phase IV clinical study of FDA data

Summary:

Large intestinal obstruction is reported as a side effect among people who take Protonix (pantoprazole sodium), especially for people who are female, 60+ old, also take Compazine, and have Crohn's disease.

The phase IV clinical study analyzes which people have Large intestinal obstruction when taking Protonix. It is created by eHealthMe based on reports of 130,073 people who have side effects when taking Protonix from the FDA, and is updated regularly.

What is Protonix?

Protonix has active ingredients of pantoprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 132,659 Protonix users. Check the latest studies of Protonix.

What is Large intestinal obstruction?

Large intestinal obstruction is found to be associated with 266 drugs and 367 conditions by eHealthMe. Check the latest studies of Large intestinal obstruction.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

130,073 people reported to have side effects when taking Protonix.
Among them, 19 people (0.01%) have Large intestinal obstruction.

Could Protonix cause Large intestinal obstruction?

Among these 19 people:

What is the gender of people who have Large intestinal obstruction when taking Protonix? *

female: 66.67 %
male: 33.33 %

What is the age of people who have Large intestinal obstruction when taking Protonix? *

What are other drugs people take besides Protonix? *

What are other side effects people have besides Large intestinal obstruction? *

Sepsis (a severe blood infection that can lead to organ failure and death): 9 people, 47.37%
Abdominal Distension: 8 people, 42.11%
Nausea (feeling of having an urge to vomit): 8 people, 42.11%
Nausea And Vomiting: 7 people, 36.84%
Small Intestinal Obstruction (blockage in small intestine): 6 people, 31.58%
Dehydration (dryness resulting from the removal of water): 6 people, 31.58%
Acute Kidney Failure: 5 people, 26.32%
Hypovolaemia (a decreased volume of circulating blood in the body): 4 people, 21.05%
Pleural Effusion (water on the lungs): 4 people, 21.05%
Death: 4 people, 21.05%

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 7 people, 36.84%
Constipation: 2 people, 10.53%
Pain: 2 people, 10.53%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 2 people, 10.53%
Stress And Anxiety: 2 people, 10.53%
Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 10.53%
High Blood Pressure: 1 person, 5.26%
Cough: 1 person, 5.26%
Depression: 1 person, 5.26%
Endometrial Cancer: 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Protonix and have Large intestinal obstruction?

- Check whether Large intestinal obstruction is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Protonix:

Protonix (132,659 reports)

Browse all side effects of Protonix:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Large intestinal obstruction:

Large intestinal obstruction (266 drugs)

Browse all the conditions that are associated with Large intestinal obstruction:

Large intestinal obstruction (367 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on pantoprazole sodium (the active ingredients of Protonix) and Protonix (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.