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Protonix and Nail dystrophy - a phase IV clinical study of FDA data

Summary:

Nail dystrophy is reported as a side effect among people who take Protonix (pantoprazole sodium), especially for people who are female, 60+ old, also take Zometa, and have Pain.

The phase IV clinical study analyzes which people have Nail dystrophy when taking Protonix. It is created by eHealthMe based on reports of 130,073 people who have side effects when taking Protonix from the FDA, and is updated regularly.

What is Protonix?

Protonix has active ingredients of pantoprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 132,658 Protonix users. Check the latest studies of Protonix.

What is Nail dystrophy?

Nail dystrophy (bed formation of nail) is found to be associated with 152 drugs and 290 conditions by eHealthMe. Check the latest studies of Nail dystrophy.

On Jul, 26, 2026

130,073 people reported to have side effects when taking Protonix.
Among them, 27 people (0.02%) have Nail dystrophy.

Could Protonix cause Nail dystrophy?

Among these 27 people:

What is the gender of people who have Nail dystrophy when taking Protonix? *

  • female: 53.85 %
  • male: 46.15 %

What is the age of people who have Nail dystrophy when taking Protonix? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 13.64 %
  • 60+: 86.36 %

What are other drugs people take besides Protonix? *

  1. Zometa: 24 people, 88.89%
  2. Neurontin: 23 people, 85.19%
  3. Oxycontin: 23 people, 85.19%
  4. Aredia: 23 people, 85.19%
  5. Dexamethasone: 21 people, 77.78%
  6. Gabapentin: 21 people, 77.78%
  7. Temazepam: 19 people, 70.37%
  8. Velcade: 18 people, 66.67%
  9. Aranesp: 18 people, 66.67%
  10. Morphine Sulfate: 14 people, 51.85%

What are other side effects people have besides Nail dystrophy? *

  1. Osteonecrosis Of Jaw (death of bone of jaw): 24 people, 88.89%
  2. Fungal Nail Infection: 23 people, 85.19%
  3. Bone Disorder: 23 people, 85.19%
  4. Osteomyelitis (infection of bone): 22 people, 81.48%
  5. Pneumonia: 21 people, 77.78%
  6. Fall: 20 people, 74.07%
  7. Hoarseness Or Changing Voice: 19 people, 70.37%
  8. Multiple Myeloma (cancer of the plasma cells): 18 people, 66.67%
  9. Onychalgia (nail biting): 18 people, 66.67%
  10. Oedema Peripheral (superficial swelling): 18 people, 66.67%

What are the existing conditions these people have? *

  1. Pain: 11 people, 40.74%
  2. Metastases To Bone (cancer spreads to bone): 10 people, 37.04%
  3. Muscle Spasms (muscle contraction): 8 people, 29.63%
  4. Stress And Anxiety: 3 people, 11.11%
  5. Pain In Jaw: 3 people, 11.11%
  6. Nerve Compression: 3 people, 11.11%
  7. Breast Cancer Recurrent: 3 people, 11.11%
  8. Breast Cancer Metastatic: 3 people, 11.11%
  9. Breast Cancer: 3 people, 11.11%
  10. Multiple Myeloma (cancer of the plasma cells): 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

Do you take Protonix and have Nail dystrophy?

- Check whether Nail dystrophy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Protonix:

Nail dystrophy treatments and more:

How severe was Nail dystrophy and when was it recovered:

Expand to all the drugs that have ingredients of pantoprazole sodium:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Protonix:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Nail dystrophy:

Browse all the conditions that are associated with Nail dystrophy:

How the study uses the data?

The study uses data from the FDA. It is based on pantoprazole sodium (the active ingredients of Protonix) and Protonix (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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