Protonix and Nonspecific reaction - a phase IV clinical study of FDA data

Summary:

Nonspecific reaction is reported as a side effect among people who take Protonix (pantoprazole sodium), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Nuplazid, and have Parkinson's disease.

The phase IV clinical study analyzes which people have Nonspecific reaction when taking Protonix. It is created by eHealthMe based on reports of 130,073 people who have side effects when taking Protonix from the FDA, and is updated regularly.

What is Protonix?

Protonix has active ingredients of pantoprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 132,659 Protonix users. Check the latest studies of Protonix.

What is Nonspecific reaction?

Nonspecific reaction (unspecified reaction) is found to be associated with 459 drugs and 437 conditions by eHealthMe. Check the latest studies of Nonspecific reaction.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

130,073 people reported to have side effects when taking Protonix.
Among them, 34 people (0.03%) have Nonspecific reaction.

Could Protonix cause Nonspecific reaction?

Among these 34 people:

How long have people been on Protonix when they have Nonspecific reaction? *

What is the gender of people who have Nonspecific reaction when taking Protonix? *

female: 62.5 %
male: 37.5 %

What is the age of people who have Nonspecific reaction when taking Protonix? *

What are other drugs people take besides Protonix? *

What are other side effects people have besides Nonspecific reaction? *

Confusional State: 7 people, 20.59%
Tremor (trembling or shaking movements in one or more parts of your body): 6 people, 17.65%
Dementia (madness): 5 people, 14.71%
Spinal Column Stenosis (narrowing of spinal column): 4 people, 11.76%
Dizziness: 4 people, 11.76%
Urinary Tract Infection: 4 people, 11.76%
Upper Limb Fracture: 4 people, 11.76%
Tumor: 4 people, 11.76%
Fall: 4 people, 11.76%
Back Disorder: 4 people, 11.76%

What are the existing conditions these people have? *

Parkinson's Disease: 9 people, 26.47%
Herpes Zoster: 4 people, 11.76%
High Blood Cholesterol: 3 people, 8.82%
High Blood Pressure: 2 people, 5.88%
Pain: 2 people, 5.88%
Hallucinations (sensations that appear real but are created by your mind): 2 people, 5.88%
Zollinger-Ellison Syndrome (increased production of the hormone gastrin from a small tumour of pancreas): 1 person, 2.94%
Asthma: 1 person, 2.94%
Complex Regional Pain Syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet)): 1 person, 2.94%
Delusion (a false belief or opinion): 1 person, 2.94%

* Approximation only. Some reports may have incomplete information.

Do you take Protonix and have Nonspecific reaction?

- Check whether Nonspecific reaction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Protonix:

Protonix (132,659 reports)

Browse all side effects of Protonix:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Nonspecific reaction:

Nonspecific reaction (459 drugs)

Browse all the conditions that are associated with Nonspecific reaction:

Nonspecific reaction (437 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on pantoprazole sodium (the active ingredients of Protonix) and Protonix (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.