Protonix and Pneumoperitoneum - a phase IV clinical study of FDA data

Summary:

Pneumoperitoneum is reported as a side effect among people who take Protonix (pantoprazole sodium), especially for people who are male, 60+ old, also take Zosyn, and have Pain.

The phase IV clinical study analyzes which people have Pneumoperitoneum when taking Protonix. It is created by eHealthMe based on reports of 130,073 people who have side effects when taking Protonix from the FDA, and is updated regularly.

What is Protonix?

Protonix has active ingredients of pantoprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 132,658 Protonix users. Check the latest studies of Protonix.

What is Pneumoperitoneum?

Pneumoperitoneum (air or gas in the abdominal (peritoneal) cavity) is found to be associated with 220 drugs and 373 conditions by eHealthMe. Check the latest studies of Pneumoperitoneum.

On Jul, 08, 2026

130,073 people reported to have side effects when taking Protonix.
Among them, 12 people (0.01%) have Pneumoperitoneum.

Among these 12 people:

What is the gender of people who have Pneumoperitoneum when taking Protonix? *

female: 50 %
male: 50 %

What is the age of people who have Pneumoperitoneum when taking Protonix? *

What are other drugs people take besides Protonix? *

What are other side effects people have besides Pneumoperitoneum? *

Gastrointestinal Perforation (hole in the digestive tract): 4 people, 33.33%
Abdominal Pain: 3 people, 25.00%
Weakness: 3 people, 25.00%
Ascites (accumulation of fluid in the abdominal cavity): 3 people, 25.00%
Thrombocytopenia (decrease of platelets in blood): 3 people, 25.00%
Rectal Haemorrhage (bleeding from anus): 3 people, 25.00%
Drug Ineffective: 2 people, 16.67%
Oesophageal Candidiasis (fungal infection of oesophagus): 2 people, 16.67%
Nausea (feeling of having an urge to vomit): 2 people, 16.67%
Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 2 people, 16.67%

What are the existing conditions these people have? *

Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 2 people, 16.67%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 16.67%
Pain: 2 people, 16.67%
High Blood Pressure: 1 person, 8.33%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 1 person, 8.33%
Cardiac Failure Congestive: 1 person, 8.33%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 1 person, 8.33%
Colon Cancer: 1 person, 8.33%
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall): 1 person, 8.33%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Protonix and have Pneumoperitoneum?

- Check whether Pneumoperitoneum is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Protonix:

Protonix (132,658 reports)

Browse all side effects of Protonix:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Pneumoperitoneum:

Pneumoperitoneum (220 drugs)

Browse all the conditions that are associated with Pneumoperitoneum:

Pneumoperitoneum (373 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on pantoprazole sodium (the active ingredients of Protonix) and Protonix (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.