Protopic and Macule - a phase IV clinical study of FDA data

Summary:

Macule is reported as a side effect among people who take Protopic (tacrolimus), especially for people who are female, 50-59 old, also take Cosentyx, and have Cutaneous lupus erythematosus.

The phase IV clinical study analyzes which people have Macule when taking Protopic. It is created by eHealthMe based on reports of 5,328 people who have side effects when taking Protopic from the FDA, and is updated regularly.

What is Protopic?

Protopic has active ingredients of tacrolimus. It is often used in eczema. eHealthMe is studying from 5,403 Protopic users. Check the latest studies of Protopic.

What is Macule?

Macule (a discoloured spot on the skin) is found to be associated with 304 drugs and 699 conditions by eHealthMe. Check the latest studies of Macule.

On Mar, 10, 2026

5,328 people reported to have side effects when taking Protopic.
Among them, 17 people (0.32%) have Macule.

Among these 17 people:

What is the gender of people who have Macule when taking Protopic? *

female: 82.35 %
male: 17.65 %

What is the age of people who have Macule when taking Protopic? *

What are other drugs people take besides Protopic? *

Cosentyx: 15 people, 88.24%
Aristocort: 8 people, 47.06%
Enbrel: 8 people, 47.06%
Enstilar: 6 people, 35.29%
Methotrexate: 5 people, 29.41%
Calcipotriene And Betamethasone Dipropionate: 4 people, 23.53%
Gabapentin: 3 people, 17.65%
Aspirin: 3 people, 17.65%
Bupropion Hydrochloride: 3 people, 17.65%
Dovonex: 3 people, 17.65%

What are other side effects people have besides Macule? *

Itching: 15 people, 88.24%
Nasal Congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels): 9 people, 52.94%
Kidney Stones: 9 people, 52.94%
Acne (skin problems that cause pimples): 8 people, 47.06%
Injection Site Bruising: 8 people, 47.06%
Skin Swelling: 8 people, 47.06%
Injection Site Pruritus (severe itching at injection site): 8 people, 47.06%
Injection Site Swelling: 8 people, 47.06%
Hair Loss: 8 people, 47.06%
Injection Site Inflammation: 6 people, 35.29%

What are the existing conditions these people have? *

Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 1 person, 5.88%
Stomatitis (inflammation of mucous membrane of mouth): 1 person, 5.88%
Skin Wrinkling (wrinkle on skin): 1 person, 5.88%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 5.88%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 5.88%
Prostate Cancer: 1 person, 5.88%
Multiple Myeloma (cancer of the plasma cells): 1 person, 5.88%
Metastasis (spreadable cancer to other organ from origin): 1 person, 5.88%
High Blood Pressure: 1 person, 5.88%
Cutaneous Lupus Erythematosus (own immune system attacks various cells causing a wide variety of signs and symptoms): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Protopic and have Macule?

- Check whether Macule is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Protopic:

Protopic (5,403 reports)

Macule treatments and more:

Macule (3,263 reports)

Browse all side effects of Protopic:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Macule:

Macule (304 drugs)

Browse all the conditions that are associated with Macule:

Macule (699 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on tacrolimus (the active ingredients of Protopic) and Protopic (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.