Provera and Mean cell volume increased - a phase IV clinical study of FDA data

Summary:

Mean cell volume increased is reported as a side effect among people who take Provera (medroxyprogesterone acetate), especially for people who are female, 20-29 old, also take Neoral, and have Aplastic anemia.

The phase IV clinical study analyzes which people have Mean cell volume increased when taking Provera. It is created by eHealthMe based on reports of 53,365 people who have side effects when taking Provera from the FDA, and is updated regularly.

What is Provera?

Provera has active ingredients of medroxyprogesterone acetate. It is often used in birth control. eHealthMe is studying from 54,943 Provera users. Check the latest studies of Provera.

What is Mean cell volume increased?

Mean cell volume increased (more than normal average red blood cell volume) is found to be associated with 456 drugs and 495 conditions by eHealthMe. Check the latest studies of Mean cell volume increased.

On Jul, 10, 2026

53,365 people reported to have side effects when taking Provera.
Among them, 13 people (0.02%) have Mean cell volume increased.

Could Provera cause Mean cell volume increased?

Among these 13 people:

What is the gender of people who have Mean cell volume increased when taking Provera? *

female: 100 %
male: 0.0 %

What is the age of people who have Mean cell volume increased when taking Provera? *

What are other drugs people take besides Provera? *

What are other side effects people have besides Mean cell volume increased? *

Gamma-Glutamyltransferase Increased: 9 people, 69.23%
Mean Cell Haemoglobin Increased (more than normal haemoglobin per red blood cell in a sample of blood): 8 people, 61.54%
Heart Rate Increased: 7 people, 53.85%
Thrombocytopenia (decrease of platelets in blood): 6 people, 46.15%
Haemoglobin Decreased: 6 people, 46.15%
Neutrophil Count Decreased (less than normal number of neutrophil a type of blood cell): 6 people, 46.15%
White Blood Cell Count Decreased: 6 people, 46.15%
Blood Magnesium Decreased: 5 people, 38.46%
Macrocytosis (enlargement of red blood cells with near-constant haemoglobin concentration): 3 people, 23.08%
Head Injury: 3 people, 23.08%

What are the existing conditions these people have? *

Aplastic Anemia: 5 people, 38.46%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 7.69%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 1 person, 7.69%
Neck Pain: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Provera and have Mean cell volume increased?

- Check whether Mean cell volume increased is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Provera:

Provera (54,943 reports)

Browse all side effects of Provera:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Mean cell volume increased:

Mean cell volume increased (456 drugs)

Browse all the conditions that are associated with Mean cell volume increased:

Mean cell volume increased (495 conditions)

Related publications that referenced our studies

Bahall M, Reyes AJ, Ramcharan K, Hosein N, Seegobin K, Bahall K, Sharma H, Dhansingh S, Mahabir A, "Neuro-ophthalmological manifestations after intramuscular medroxyprogesterone: a forme fruste of idiopathic intracranial hypertension?", Neurology international, 2016 Sep .
Bahall M, Reyes AJ, Ramcharan K, Hosein N, Seegobin K, Bahall K, Sharma H, Dhansingh S, Mahabir A, "Neuro-ophthalmological manifestations after intramuscular medroxyprogesterone: a forme fruste of idiopathic intracranial hypertension?", Neurology international, 2016 Sep .

How the study uses the data?

The study uses data from the FDA. It is based on medroxyprogesterone acetate (the active ingredients of Provera) and Provera (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.