Provera and Muscle tightness - a phase IV clinical study of FDA data

Summary:

Muscle tightness is reported as a side effect among people who take Provera (medroxyprogesterone acetate), especially for people who are female, 20-29 old, have been taking the drug for 5 - 10 years also take Premarin, and have Menopause.

The phase IV clinical study analyzes which people have Muscle tightness when taking Provera. It is created by eHealthMe based on reports of 53,365 people who have side effects when taking Provera from the FDA, and is updated regularly.

What is Provera?

Provera has active ingredients of medroxyprogesterone acetate. It is often used in birth control. eHealthMe is studying from 54,943 Provera users. Check the latest studies of Provera.

What is Muscle tightness?

Muscle tightness is found to be associated with 1,071 drugs and 1,025 conditions by eHealthMe. Check the latest studies of Muscle tightness.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

53,365 people reported to have side effects when taking Provera.
Among them, 53 people (0.1%) have Muscle tightness.

Among these 53 people:

How long have people been on Provera when they have Muscle tightness? *

What is the gender of people who have Muscle tightness when taking Provera? *

female: 96.23 %
male: 3.77 %

What is the age of people who have Muscle tightness when taking Provera? *

What are other drugs people take besides Provera? *

What are other side effects people have besides Muscle tightness? *

Nausea (feeling of having an urge to vomit): 20 people, 37.74%
Dizziness: 19 people, 35.85%
Pain: 18 people, 33.96%
Depression: 17 people, 32.08%
Headache (pain in head): 15 people, 28.30%
Dyspnea (difficult or laboured breathing): 15 people, 28.30%
Chest Pain: 14 people, 26.42%
Fatigue (feeling of tiredness): 13 people, 24.53%
Pain In Extremity: 13 people, 24.53%
Weakness: 13 people, 24.53%

What are the existing conditions these people have? *

Menopause (end of monthly cycles in women): 8 people, 15.09%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 7 people, 13.21%
Depression: 6 people, 11.32%
Pain: 5 people, 9.43%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 7.55%
Osteoporosis (bones weak and more likely to break): 4 people, 7.55%
Diabetes: 4 people, 7.55%
High Blood Cholesterol: 4 people, 7.55%
Skin Irritation: 2 people, 3.77%
Back Pain: 2 people, 3.77%

* Approximation only. Some reports may have incomplete information.

Do you take Provera and have Muscle tightness?

- Check whether Muscle tightness is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Provera:

Provera (54,943 reports)

Muscle tightness treatments and more:

Muscle tightness (19,728 reports)

Browse all side effects of Provera:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Muscle tightness:

Muscle tightness (1,071 drugs)

Browse all the conditions that are associated with Muscle tightness:

Muscle tightness (1,025 conditions)

Related publications that referenced our studies

Bahall M, Reyes AJ, Ramcharan K, Hosein N, Seegobin K, Bahall K, Sharma H, Dhansingh S, Mahabir A, "Neuro-ophthalmological manifestations after intramuscular medroxyprogesterone: a forme fruste of idiopathic intracranial hypertension?", Neurology international, 2016 Sep .
Bahall M, Reyes AJ, Ramcharan K, Hosein N, Seegobin K, Bahall K, Sharma H, Dhansingh S, Mahabir A, "Neuro-ophthalmological manifestations after intramuscular medroxyprogesterone: a forme fruste of idiopathic intracranial hypertension?", Neurology international, 2016 Sep .

How the study uses the data?

The study uses data from the FDA. It is based on medroxyprogesterone acetate (the active ingredients of Provera) and Provera (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.