Provera and Oligomenorrhea - a phase IV clinical study of FDA data

Summary:

Oligomenorrhea is reported as a side effect among people who take Provera (medroxyprogesterone acetate), especially for people who are female, 30-39 old, have been taking the drug for < 1 month also take Arava, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Oligomenorrhea when taking Provera. It is created by eHealthMe based on reports of 53,365 people who have side effects when taking Provera from the FDA, and is updated regularly.

What is Provera?

Provera has active ingredients of medroxyprogesterone acetate. It is often used in birth control. eHealthMe is studying from 54,943 Provera users. Check the latest studies of Provera.

What is Oligomenorrhea?

Oligomenorrhea is found to be associated with 131 drugs and 315 conditions by eHealthMe. Check the latest studies of Oligomenorrhea.



On Apr, 24, 2026

53,365 people reported to have side effects when taking Provera.
Among them, 41 people (0.08%) have Oligomenorrhea.

Could Provera cause Oligomenorrhea?

Among these 41 people:

How long have people been on Provera when they have Oligomenorrhea? *

  • < 1 month: 57.14 %
  • 1 - 6 months: 28.57 %
  • 6 - 12 months: 7.14 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 7.14 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Oligomenorrhea when taking Provera? *

  • female: 100 %
  • male: 0.0 %

What is the age of people who have Oligomenorrhea when taking Provera? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 26.32 %
  • 20-29: 31.58 %
  • 30-39: 36.84 %
  • 40-49: 5.26 %
  • 50-59: 0.0 %
  • 60+: 0.0 %

What are other drugs people take besides Provera? *

  1. Actemra: 9 people, 21.95%
  2. Arava: 9 people, 21.95%
  3. Prednisone: 5 people, 12.20%
  4. Desoximetasone: 5 people, 12.20%
  5. Clozaril: 2 people, 4.88%
  6. Mirena: 2 people, 4.88%
  7. Zantac: 2 people, 4.88%
  8. Claravis: 1 person, 2.44%
  9. Clopidogrel: 1 person, 2.44%
  10. Biotin: 1 person, 2.44%

What are other side effects people have besides Oligomenorrhea? *

  1. Headache (pain in head): 15 people, 36.59%
  2. Weight Increased: 15 people, 36.59%
  3. Abdominal Pain: 11 people, 26.83%
  4. Body Temperature Increased: 10 people, 24.39%
  5. Respiratory Tract Infection: 9 people, 21.95%
  6. Sinusitis (inflammation of sinus): 9 people, 21.95%
  7. General Physical Health Deterioration (weak health status): 9 people, 21.95%
  8. Nosebleed (bleeding from nose): 9 people, 21.95%
  9. Oropharyngeal Pain: 9 people, 21.95%
  10. Otitis (ear infection): 9 people, 21.95%

What are the existing conditions these people have? *

  1. Sinus Congestion (blockage of sinus): 9 people, 21.95%
  2. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 9 people, 21.95%
  3. Heavy Or Prolong Menstrual Bleeding: 3 people, 7.32%
  4. Vitamin B12 Deficiency: 2 people, 4.88%
  5. Uterine Leiomyoma (uterine benign tumour derived from smooth muscle): 2 people, 4.88%
  6. Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 2 people, 4.88%
  7. Uterine Disorder: 1 person, 2.44%
  8. Restless Leg Syndrome (a powerful urge to move your legs): 1 person, 2.44%
  9. Psoriasis (immune-mediated disease that affects the skin): 1 person, 2.44%
  10. Pelvic Pain: 1 person, 2.44%

* Approximation only. Some reports may have incomplete information.

Do you take Provera and have Oligomenorrhea?

- Check whether Oligomenorrhea is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, long term effects of, and alternative drugs to Provera:

Oligomenorrhea treatments and more:

How severe was Oligomenorrhea and when was it recovered:

Expand to all the drugs that have ingredients of medroxyprogesterone acetate:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Provera:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Oligomenorrhea:

Browse all the conditions that are associated with Oligomenorrhea:

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on medroxyprogesterone acetate (the active ingredients of Provera) and Provera (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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