Provigil and Anhedonia - a phase IV clinical study of FDA data

Summary:

Anhedonia is reported as a side effect among people who take Provigil (modafinil), especially for people who are female, 50-59 old, have been taking the drug for 10+ years also take Zometa, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Anhedonia when taking Provigil. It is created by eHealthMe based on reports of 23,659 people who have side effects when taking Provigil from the FDA, and is updated regularly.

What is Provigil?

Provigil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 25,230 Provigil users. Check the latest studies of Provigil.

What is Anhedonia?

Anhedonia (inability to experience pleasure from activities usually found enjoyable) is found to be associated with 1,512 drugs and 1,274 conditions by eHealthMe. Check the latest studies of Anhedonia.

On Jul, 04, 2026

23,659 people reported to have side effects when taking Provigil.
Among them, 92 people (0.39%) have Anhedonia.

Among these 92 people:

How long have people been on Provigil when they have Anhedonia? *

What is the gender of people who have Anhedonia when taking Provigil? *

female: 68.48 %
male: 31.52 %

What is the age of people who have Anhedonia when taking Provigil? *

What are other drugs people take besides Provigil? *

What are other side effects people have besides Anhedonia? *

Pain: 82 people, 89.13%
Stress And Anxiety: 77 people, 83.70%
High Blood Pressure: 51 people, 55.43%
Tooth Fracture: 45 people, 48.91%
Emotional Distress: 43 people, 46.74%
Anaemia (lack of blood): 42 people, 45.65%
Weakness: 41 people, 44.57%
Bone Disorder: 39 people, 42.39%
Pain In Jaw: 39 people, 42.39%
Injury: 38 people, 41.30%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 28 people, 30.43%
High Blood Pressure: 27 people, 29.35%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 26 people, 28.26%
Depression: 15 people, 16.30%
Pain: 11 people, 11.96%
Hiv Infection: 10 people, 10.87%
Insomnia (sleeplessness): 9 people, 9.78%
High Blood Cholesterol: 8 people, 8.70%
Hypersensitivity: 6 people, 6.52%
Stress And Anxiety: 6 people, 6.52%

* Approximation only. Some reports may have incomplete information.

Do you take Provigil and have Anhedonia?

- Check whether Anhedonia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Provigil:

Provigil (25,230 reports)

Anhedonia treatments and more:

Anhedonia (51,943 reports)

Browse all side effects of Provigil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Anhedonia:

Anhedonia (1,512 drugs)

Browse all the conditions that are associated with Anhedonia:

Anhedonia (1,274 conditions)

Related publications that referenced our studies

Lopes E, Pereira D, da Silva Behrens NS, de Almeida Fonseca H, Calvancanti PO, de Araújo Lima TF, Pradella-Hallinan M, Castro J, Tufik S, Coelho FM, "Cataplexy as a side effect of modafinil in a patient without narcolepsy", Sleep Science, 2014 Mar .
Lopes E, Pereira D, da Silva Behrens NS, de Almeida Fonseca H, Calvancanti PO, de Araújo Lima TF, Pradella-Hallinan M, Castro J, Tufik S, Coelho FM, "Cataplexy as a side effect of modafinil in a patient without narcolepsy", Sleep Science, 2014 Mar .

How the study uses the data?

The study uses data from the FDA. It is based on modafinil (the active ingredients of Provigil) and Provigil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.