Provigil and Platelet count increased - a phase IV clinical study of FDA data

Summary:

Platelet count increased is reported as a side effect among people who take Provigil (modafinil), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Percocet, and have Osteoporosis.

The phase IV clinical study analyzes which people have Platelet count increased when taking Provigil. It is created by eHealthMe based on reports of 23,659 people who have side effects when taking Provigil from the FDA, and is updated regularly.

What is Provigil?

Provigil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 25,230 Provigil users. Check the latest studies of Provigil.

What is Platelet count increased?

Platelet count increased is found to be associated with 956 drugs and 1,190 conditions by eHealthMe. Check the latest studies of Platelet count increased.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 22, 2026

23,659 people reported to have side effects when taking Provigil.
Among them, 37 people (0.16%) have Platelet count increased.

Could Provigil cause Platelet count increased?

Among these 37 people:

How long have people been on Provigil when they have Platelet count increased? *

What is the gender of people who have Platelet count increased when taking Provigil? *

female: 100 %
male: 0.0 %

What is the age of people who have Platelet count increased when taking Provigil? *

What are other drugs people take besides Provigil? *

What are other side effects people have besides Platelet count increased? *

Swallowing Difficulty: 25 people, 67.57%
Acute Kidney Failure: 25 people, 67.57%
Oedema Peripheral (superficial swelling): 24 people, 64.86%
Sinusitis (inflammation of sinus): 24 people, 64.86%
Sepsis (a severe blood infection that can lead to organ failure and death): 24 people, 64.86%
Pain: 24 people, 64.86%
Generalised Oedema (swelling all over the body): 24 people, 64.86%
Uterine Leiomyoma (uterine benign tumour derived from smooth muscle): 24 people, 64.86%
Mouth Ulcers: 23 people, 62.16%
Metastatic Neoplasm (spreadable cancer tumour): 23 people, 62.16%

What are the existing conditions these people have? *

Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 23 people, 62.16%
Osteoporosis (bones weak and more likely to break): 23 people, 62.16%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 9 people, 24.32%
Thrombocytopenia (decrease of platelets in blood): 7 people, 18.92%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 5.41%
Pain: 2 people, 5.41%
High Blood Pressure: 2 people, 5.41%
Neurogenic Bladder (the normal function of the bladder is to store and empty urine in a coordinated, controlled fashion): 1 person, 2.70%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 1 person, 2.70%
Idiopathic Thrombocytopenic Purpura (Itp) (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting): 1 person, 2.70%

* Approximation only. Some reports may have incomplete information.

Do you take Provigil and have Platelet count increased?

- Check whether Platelet count increased is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Provigil:

Provigil (25,230 reports)

Browse all side effects of Provigil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Platelet count increased:

Platelet count increased (956 drugs)

Browse all the conditions that are associated with Platelet count increased:

Platelet count increased (1,190 conditions)

Related publications that referenced our studies

Lopes E, Pereira D, da Silva Behrens NS, de Almeida Fonseca H, Calvancanti PO, de Araújo Lima TF, Pradella-Hallinan M, Castro J, Tufik S, Coelho FM, "Cataplexy as a side effect of modafinil in a patient without narcolepsy", Sleep Science, 2014 Mar .
Lopes E, Pereira D, da Silva Behrens NS, de Almeida Fonseca H, Calvancanti PO, de Araújo Lima TF, Pradella-Hallinan M, Castro J, Tufik S, Coelho FM, "Cataplexy as a side effect of modafinil in a patient without narcolepsy", Sleep Science, 2014 Mar .

How the study uses the data?

The study uses data from the FDA. It is based on modafinil (the active ingredients of Provigil) and Provigil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.