Prozac and Polysubstance abuse - a phase IV clinical study of FDA data

Summary:

Polysubstance abuse is reported as a side effect among people who take Prozac (fluoxetine hydrochloride), especially for people who are female, 50-59 old, also take Oxycontin, and have Pain.

The phase IV clinical study analyzes which people have Polysubstance abuse when taking Prozac. It is created by eHealthMe based on reports of 74,788 people who have side effects when taking Prozac from the FDA, and is updated regularly.

What is Prozac?

Prozac has active ingredients of fluoxetine hydrochloride. It is often used in depression. eHealthMe is studying from 82,988 Prozac users. Check the latest studies of Prozac.

What is Polysubstance abuse?

Polysubstance abuse is found to be associated with 89 drugs and 66 conditions by eHealthMe. Check the latest studies of Polysubstance abuse.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

74,788 people reported to have side effects when taking Prozac.
Among them, 28 people (0.04%) have Polysubstance abuse.

Among these 28 people:

What is the gender of people who have Polysubstance abuse when taking Prozac? *

female: 85.71 %
male: 14.29 %

What is the age of people who have Polysubstance abuse when taking Prozac? *

What are other drugs people take besides Prozac? *

What are other side effects people have besides Polysubstance abuse? *

Drug Dependence: 24 people, 85.71%
Joint Pain: 22 people, 78.57%
Pain In Extremity: 21 people, 75.00%
Pain: 21 people, 75.00%
Suicidal Ideation: 21 people, 75.00%
Drug Withdrawal Syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 20 people, 71.43%
Mood Swings (an extreme or rapid change in mood): 20 people, 71.43%
Pollakiuria (abnormally frequent passage of relatively small quantities or urine): 20 people, 71.43%
Constipation: 19 people, 67.86%
Back Pain: 19 people, 67.86%

What are the existing conditions these people have? *

Pain: 14 people, 50.00%
Schizoaffective Disorder (a mental disorder characterized by disordered thought): 1 person, 3.57%

* Approximation only. Some reports may have incomplete information.

Do you take Prozac and have Polysubstance abuse?

- Check whether Polysubstance abuse is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Prozac:

Prozac (82,988 reports)

Browse all side effects of Prozac:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Polysubstance abuse:

Polysubstance abuse (89 drugs)

Browse all the conditions that are associated with Polysubstance abuse:

Polysubstance abuse (66 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on fluoxetine hydrochloride (the active ingredients of Prozac) and Prozac (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.