Prozac and Sciatica - a phase IV clinical study of FDA data

Summary:

Sciatica is reported as a side effect among people who take Prozac (fluoxetine hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 10+ years also take Zometa, and have High blood cholesterol.

The phase IV clinical study analyzes which people have Sciatica when taking Prozac. It is created by eHealthMe based on reports of 74,788 people who have side effects when taking Prozac from the FDA, and is updated regularly.

What is Prozac?

Prozac has active ingredients of fluoxetine hydrochloride. It is often used in depression. eHealthMe is studying from 82,977 Prozac users. Check the latest studies of Prozac.

What is Sciatica?

Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve) is found to be associated with 1,147 drugs and 1,419 conditions by eHealthMe. Check the latest studies of Sciatica.

On Dec, 05, 2025

74,788 people reported to have side effects when taking Prozac.
Among them, 163 people (0.22%) have Sciatica.

Among these 163 people:

How long have people been on Prozac when they have Sciatica? *

What is the gender of people who have Sciatica when taking Prozac? *

female: 65.82 %
male: 34.18 %

What is the age of people who have Sciatica when taking Prozac? *

What are other drugs people take besides Prozac? *

What are other side effects people have besides Sciatica? *

Back Pain: 71 people, 43.56%
Pain: 67 people, 41.10%
Fatigue (feeling of tiredness): 66 people, 40.49%
Fall: 51 people, 31.29%
Joint Pain: 51 people, 31.29%
Nausea (feeling of having an urge to vomit): 47 people, 28.83%
Pain In Extremity: 46 people, 28.22%
Anaemia (lack of blood): 46 people, 28.22%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 45 people, 27.61%
Pneumonia: 44 people, 26.99%

What are the existing conditions these people have? *

High Blood Cholesterol: 23 people, 14.11%
Osteoporosis (bones weak and more likely to break): 22 people, 13.50%
High Blood Pressure: 16 people, 9.82%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 16 people, 9.82%
Pain: 12 people, 7.36%
Prostate Cancer Metastatic: 11 people, 6.75%
Back Pain: 11 people, 6.75%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 11 people, 6.75%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 10 people, 6.13%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 6.13%

* Approximation only. Some reports may have incomplete information.

Do you take Prozac and have Sciatica?

- Check whether Sciatica is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Prozac:

Prozac (82,977 reports)

Sciatica treatments and more:

Sciatica (28,506 reports)

Common Prozac side effects:

Browse all side effects of Prozac:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Sciatica:

Browse all the drugs that are associated with Sciatica:

Sciatica (1,147 drugs)

Common conditions associated with Sciatica:

Ra: 3,984 reports
Osteoporosis: 1,578 reports
Psoriatic arthropathy aggravated: 1,283 reports
Pain: 1,076 reports
Pain relief: 1,069 reports
Ms: 1,038 reports
Hypertension: 930 reports
Htn: 922 reports
Hypercholesterolaemia: 804 reports
Psoriasis: 785 reports

Browse all the conditions that are associated with Sciatica:

Sciatica (1,419 conditions)

Drugs similar to Prozac and Sciatica :

How the study uses the data?

The study uses data from the FDA. It is based on fluoxetine hydrochloride (the active ingredients of Prozac) and Prozac (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.