Pylera and Depression - a phase IV clinical study of FDA data

Summary:

Depression is reported as a side effect among people who take Pylera (bismuth subcitrate potassium; metronidazole; tetracycline), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Cymbalta, and have Helicobacter infection.

The phase IV clinical study analyzes which people have Depression when taking Pylera. It is created by eHealthMe based on reports of 1,008 people who have side effects when taking Pylera from the FDA, and is updated regularly.

What is Pylera?

Pylera has active ingredients of bismuth subcitrate potassium; metronidazole; tetracycline. eHealthMe is studying from 1,036 Pylera users. Check the latest studies of Pylera.

What is Depression?

Depression is found to be associated with 3,167 drugs and 4,125 conditions by eHealthMe. Check the latest studies of Depression.

On Jul, 19, 2026

1,008 people reported to have side effects when taking Pylera.
Among them, 24 people (2.38%) have Depression.

Among these 24 people:

How long have people been on Pylera when they have Depression? *

What is the gender of people who have Depression when taking Pylera? *

female: 65.22 %
male: 34.78 %

What is the age of people who have Depression when taking Pylera? *

What are other drugs people take besides Pylera? *

What are other side effects people have besides Depression? *

Stress And Anxiety: 13 people, 54.17%
Pain: 6 people, 25.00%
Weakness: 6 people, 25.00%
Fatigue (feeling of tiredness): 6 people, 25.00%
Suicidal Ideation: 4 people, 16.67%
Dizziness: 4 people, 16.67%
Drowsiness: 4 people, 16.67%
Epigastric Discomfort: 3 people, 12.50%
Herpes Zoster: 3 people, 12.50%
Gingival Bleeding (bleeding gums): 3 people, 12.50%

What are the existing conditions these people have? *

Helicobacter Infection (helicobacter pylori (h. pylori) infects stomach): 10 people, 41.67%
Hiv Infection: 3 people, 12.50%
Helicobacter Gastritis (inflammation of the inner lining of the stomach caused by helicobacter pylori (h. pylori) a bacterium): 3 people, 12.50%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 8.33%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 8.33%
Hepatitis C: 1 person, 4.17%
Gastroduodenal Ulcer: 1 person, 4.17%
Gastric Ulcer Helicobacter (ulcer caused by helicobacter bacteria): 1 person, 4.17%
Gastric Ulcer (stomach ulcer): 1 person, 4.17%

* Approximation only. Some reports may have incomplete information.

Do you take Pylera and have Depression?

- Check whether Depression is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Pylera:

Pylera (1,036 reports)

Depression treatments and more:

Depression (652,144 reports)

How severe was Depression and when was it recovered:

Depression in Pylera

Expand to all the drugs that have ingredients of bismuth subcitrate potassium; metronidazole; tetracycline:

Depression and drugs with ingredients of bismuth subcitrate potassium; metronidazole; tetracycline (24 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Pylera:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Depression:

Depression (3,167 drugs)

Browse all the conditions that are associated with Depression:

Depression (4,125 conditions)

Related publications that referenced our studies

Pang, T., & Gudi, A., "Chest pain following the use of fluvoxamine in depression", Proceedings of Singapore Healthcare, 2018 Jan .
Pang, T., & Gudi, A., "Chest pain following the use of fluvoxamine in depression", Proceedings of Singapore Healthcare, 2018 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on bismuth subcitrate potassium; metronidazole; tetracycline (the active ingredients of Pylera) and Pylera (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.