Pyrazinamide and Central nervous system lesion - a phase IV clinical study of FDA data

Summary:

Central nervous system lesion is reported as a side effect among people who take Pyrazinamide (pyrazinamide), especially for people who are male, 30-39 old, have been taking the drug for < 1 month also take Isoniazid, and have Hiv infection.

The phase IV clinical study analyzes which people have Central nervous system lesion when taking Pyrazinamide. It is created by eHealthMe based on reports of 10,019 people who have side effects when taking Pyrazinamide from the FDA, and is updated regularly.

What is Pyrazinamide?

Pyrazinamide has active ingredients of pyrazinamide. It is often used in tuberculosis. eHealthMe is studying from 10,062 Pyrazinamide users. Check the latest studies of Pyrazinamide.

What is Central nervous system lesion?

Central nervous system lesion (an abnormality in tissue of brain or spinal cord) is found to be associated with 779 drugs and 824 conditions by eHealthMe. Check the latest studies of Central nervous system lesion.

On Aug, 07, 2026

10,019 people reported to have side effects when taking Pyrazinamide.
Among them, 19 people (0.19%) have Central nervous system lesion.

Could Pyrazinamide cause Central nervous system lesion?

Among these 19 people:

How long have people been on Pyrazinamide when they have Central nervous system lesion? *

What is the gender of people who have Central nervous system lesion when taking Pyrazinamide? *

female: 44.44 %
male: 55.56 %

What is the age of people who have Central nervous system lesion when taking Pyrazinamide? *

What are other drugs people take besides Pyrazinamide? *

What are other side effects people have besides Central nervous system lesion? *

Fever: 11 people, 57.89%
Disseminated Tuberculosis: 7 people, 36.84%
Lymph Follicular Hypertrophy (an increase in the size of the lymph node follicles): 5 people, 26.32%
Cough: 5 people, 26.32%
Pulmonary Tuberculosis (lungs tuberculosis): 4 people, 21.05%
Confusional State: 4 people, 21.05%
Abdominal Pain: 4 people, 21.05%
General Physical Health Deterioration (weak health status): 4 people, 21.05%
Confusion: 3 people, 15.79%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 3 people, 15.79%

What are the existing conditions these people have? *

Hiv Infection: 6 people, 31.58%
Pulmonary Tuberculosis (lungs tuberculosis): 4 people, 21.05%
Disseminated Tuberculosis: 3 people, 15.79%
Meningitis Tuberculous (a bacterial infection of the membranes covering the brain and spinal cord (meninges)): 2 people, 10.53%
Inflammation: 2 people, 10.53%
Epstein-Barr Virus Infection: 2 people, 10.53%
Tuberculosis Of Central Nervous System (a bacterial infection of brain and spinal cord by mycobacterium tuberculosis): 1 person, 5.26%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 1 person, 5.26%
Lymph Node Tuberculosis: 1 person, 5.26%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Pyrazinamide and have Central nervous system lesion?

- Check whether Central nervous system lesion is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Pyrazinamide:

Pyrazinamide (10,062 reports)

Browse all side effects of Pyrazinamide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Central nervous system lesion:

Central nervous system lesion (779 drugs)

Browse all the conditions that are associated with Central nervous system lesion:

Central nervous system lesion (824 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on pyrazinamide (the active ingredients of Pyrazinamide) and Pyrazinamide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.