Rabeprazole and Knee joint replacement - a phase IV clinical study of FDA data

Summary:

Knee joint replacement is reported as a side effect among people who take Rabeprazole (rabeprazole sodium), especially for people who are female, 60+ old, have been taking the drug for 1 - 2 years also take Atrovent, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Knee joint replacement when taking Rabeprazole. It is created by eHealthMe based on reports of 31,196 people who have side effects when taking Rabeprazole from the FDA, and is updated regularly.

What is Rabeprazole?

Rabeprazole has active ingredients of rabeprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 31,689 Rabeprazole users. Check the latest studies of Rabeprazole.

What is Knee joint replacement?

Knee joint replacement is found to be associated with 954 drugs and 1,228 conditions by eHealthMe. Check the latest studies of Knee joint replacement.

On Jul, 13, 2026

31,196 people reported to have side effects when taking Rabeprazole.
Among them, 38 people (0.12%) have Knee joint replacement.

Could Rabeprazole cause Knee joint replacement?

Among these 38 people:

How long have people been on Rabeprazole when they have Knee joint replacement? *

What is the gender of people who have Knee joint replacement when taking Rabeprazole? *

female: 88.24 %
male: 11.76 %

What is the age of people who have Knee joint replacement when taking Rabeprazole? *

What are other drugs people take besides Rabeprazole? *

What are other side effects people have besides Knee joint replacement? *

High Blood Pressure: 17 people, 44.74%
Dyspnea (difficult or laboured breathing): 14 people, 36.84%
Drug Ineffective: 13 people, 34.21%
Sternitis (inflammation of the sternum): 12 people, 31.58%
Aortic Stenosis (obstruction to the outflow of blood from the left ventricle into the aorta): 12 people, 31.58%
Wheezing (a high-pitched whistling sound made while you breath): 12 people, 31.58%
Dyslipidaemia (abnormal amount of lipids): 12 people, 31.58%
Staphylococcal Infection (an infection with staphylococcus bacteria): 12 people, 31.58%
Joint Pain: 11 people, 28.95%
Pain: 8 people, 21.05%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 12 people, 31.58%
Wheezing (a high-pitched whistling sound made while you breath): 5 people, 13.16%
Asthma: 5 people, 13.16%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 4 people, 10.53%
High Blood Cholesterol: 2 people, 5.26%
Ankylosing Spondylitis (type of arthritis affecting the spine): 2 people, 5.26%
Constipation: 2 people, 5.26%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 2 people, 5.26%
Depression: 2 people, 5.26%
Agitation (state of anxiety or nervous excitement): 2 people, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Rabeprazole and have Knee joint replacement?

- Check whether Knee joint replacement is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Rabeprazole:

Rabeprazole (31,689 reports)

Browse all side effects of Rabeprazole:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Knee joint replacement:

Knee joint replacement (954 drugs)

Browse all the conditions that are associated with Knee joint replacement:

Knee joint replacement (1,228 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on rabeprazole sodium (the active ingredients of Rabeprazole) and Rabeprazole (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.