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Rapamune and Urticaria - a phase IV clinical study of FDA data

Summary:

Urticaria is reported as a side effect among people who take Rapamune (sirolimus), especially for people who are female, 50-59 old, have been taking the drug for 1 - 6 months also take Prednisone, and have Sarcoma.

The phase IV clinical study analyzes which people have Urticaria when taking Rapamune. It is created by eHealthMe based on reports of 13,732 people who have side effects when taking Rapamune from the FDA, and is updated regularly.

What is Rapamune?

Rapamune has active ingredients of sirolimus. It is often used in kidney transplant. eHealthMe is studying from 13,848 Rapamune users. Check the latest studies of Rapamune.

What is Urticaria?

Urticaria (rash of round, red welts on the skin that itch intensely) is found to be associated with 2,618 drugs and 2,953 conditions by eHealthMe. Check the latest studies of Urticaria.

On Jul, 21, 2026

13,732 people reported to have side effects when taking Rapamune.
Among them, 28 people (0.2%) have Urticaria.

Could Rapamune cause Urticaria?

Among these 28 people:

How long have people been on Rapamune when they have Urticaria? *

  • < 1 month: 44.44 %
  • 1 - 6 months: 55.56 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Urticaria when taking Rapamune? *

  • female: 55.56 %
  • male: 44.44 %

What is the age of people who have Urticaria when taking Rapamune? *

  • 0-1: 4.35 %
  • 2-9: 8.7 %
  • 10-19: 4.35 %
  • 20-29: 13.04 %
  • 30-39: 4.35 %
  • 40-49: 8.7 %
  • 50-59: 39.13 %
  • 60+: 17.39 %

What are other drugs people take besides Rapamune? *

  1. Prednisone: 8 people, 28.57%
  2. Bactrim: 7 people, 25.00%
  3. Gabapentin: 6 people, 21.43%
  4. Keppra: 6 people, 21.43%
  5. Prograf: 5 people, 17.86%
  6. Novolog: 4 people, 14.29%
  7. Cellcept: 4 people, 14.29%
  8. Diflucan: 4 people, 14.29%
  9. Pravachol: 4 people, 14.29%
  10. Zolpidem: 4 people, 14.29%

What are other side effects people have besides Urticaria? *

  1. Rashes (redness): 9 people, 32.14%
  2. Diarrhea: 6 people, 21.43%
  3. Itching: 5 people, 17.86%
  4. Drug Ineffective: 4 people, 14.29%
  5. Stomatitis (inflammation of mucous membrane of mouth): 3 people, 10.71%
  6. Pain: 3 people, 10.71%
  7. Hepatic Mass: 3 people, 10.71%
  8. Dysmenorrhea (painful menstruation): 3 people, 10.71%
  9. Renal Mass (mass in kidney): 3 people, 10.71%
  10. Constipation: 3 people, 10.71%

What are the existing conditions these people have? *

  1. Sarcoma (rare cancers that develop in the muscle, bone, nerves, cartilage, tendons, blood vessels and the fatty and fibrous tissues): 5 people, 17.86%
  2. Angiomyolipoma (most common benign tumour of the kidney): 3 people, 10.71%
  3. Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 7.14%
  4. Breast Cancer Metastatic: 2 people, 7.14%
  5. Intracardiac Thrombus (presence of a circumscribed mass with heart wall): 2 people, 7.14%
  6. Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 2 people, 7.14%
  7. Thrombosis (formation of a blood clot inside a blood vessel): 2 people, 7.14%
  8. Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 2 people, 7.14%
  9. Diarrhea: 2 people, 7.14%
  10. Tuberous Sclerosis (a rare genetic disease that causes benign tumours to grow in the brain and other organs): 1 person, 3.57%

* Approximation only. Some reports may have incomplete information.

Do you take Rapamune and have Urticaria?

- Check whether Urticaria is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Rapamune:

Urticaria treatments and more:

How severe was Urticaria and when was it recovered:

Expand to all the drugs that have ingredients of sirolimus:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Rapamune:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Urticaria:

Browse all the conditions that are associated with Urticaria:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on sirolimus (the active ingredients of Rapamune) and Rapamune (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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