Rebif and Muscle rupture - a phase IV clinical study of FDA data

Summary:

Muscle rupture is reported as a side effect among people who take Rebif (interferon beta-1a), especially for people who are male, 60+ old, have been taking the drug for 1 - 6 months also take Klonopin, and have Constipation.

The phase IV clinical study analyzes which people have Muscle rupture when taking Rebif. It is created by eHealthMe based on reports of 60,837 people who have side effects when taking Rebif from the FDA, and is updated regularly.

What is Rebif?

Rebif has active ingredients of interferon beta-1a. It is often used in multiple sclerosis. eHealthMe is studying from 61,126 Rebif users. Check the latest studies of Rebif.

What is Muscle rupture?

Muscle rupture (tear in muscle) is found to be associated with 395 drugs and 509 conditions by eHealthMe. Check the latest studies of Muscle rupture.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

60,837 people reported to have side effects when taking Rebif.
Among them, 15 people (0.02%) have Muscle rupture.

Among these 15 people:

How long have people been on Rebif when they have Muscle rupture? *

What is the gender of people who have Muscle rupture when taking Rebif? *

female: 28.57 %
male: 71.43 %

What is the age of people who have Muscle rupture when taking Rebif? *

What are other drugs people take besides Rebif? *

What are other side effects people have besides Muscle rupture? *

Fall: 6 people, 40.00%
Eye Disorder: 5 people, 33.33%
Tremor (trembling or shaking movements in one or more parts of your body): 3 people, 20.00%
Gait Disturbance: 3 people, 20.00%
Rotator Cuff Syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder): 3 people, 20.00%
Meniscus Lesion (lesion of a crescent-shaped piece of cartilage between the femur and the tibia): 3 people, 20.00%
Joint Injury: 2 people, 13.33%
Intervertebral Disc Protrusion (spinal disc protrusion): 2 people, 13.33%
Pain: 2 people, 13.33%
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve): 2 people, 13.33%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 6.67%
Psoriasis (immune-mediated disease that affects the skin): 1 person, 6.67%
Pain: 1 person, 6.67%
Neuralgia (pain in one or more nerves): 1 person, 6.67%
Insomnia (sleeplessness): 1 person, 6.67%
Hyperlipidaemia (presence of excess lipids in the blood): 1 person, 6.67%
High Blood Pressure: 1 person, 6.67%
Heart Rate Irregular: 1 person, 6.67%
Faeces Hard: 1 person, 6.67%
Constipation: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Rebif and have Muscle rupture?

- Check whether Muscle rupture is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Rebif:

Rebif (61,126 reports)

Muscle rupture treatments and more:

Muscle rupture (4,655 reports)

Browse all side effects of Rebif:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Muscle rupture:

Muscle rupture (395 drugs)

Browse all the conditions that are associated with Muscle rupture:

Muscle rupture (509 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on interferon beta-1a (the active ingredients of Rebif) and Rebif (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.