Reclast and Lymphoedema - a phase IV clinical study of FDA data

Summary:

Lymphoedema is reported as a side effect among people who take Reclast (zoledronic acid), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Lyrica, and have Seasonal allergy.

The phase IV clinical study analyzes which people have Lymphoedema when taking Reclast. It is created by eHealthMe based on reports of 15,446 people who have side effects when taking Reclast from the FDA, and is updated regularly.

What is Reclast?

Reclast has active ingredients of zoledronic acid. It is often used in osteoporosis. eHealthMe is studying from 15,774 Reclast users. Check the latest studies of Reclast.

What is Lymphoedema?

Lymphoedema (localized fluid retention and tissue swelling) is found to be associated with 911 drugs and 743 conditions by eHealthMe. Check the latest studies of Lymphoedema.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

15,446 people reported to have side effects when taking Reclast.
Among them, 19 people (0.12%) have Lymphoedema.

Among these 19 people:

How long have people been on Reclast when they have Lymphoedema? *

What is the gender of people who have Lymphoedema when taking Reclast? *

female: 94.12 %
male: 5.88 %

What is the age of people who have Lymphoedema when taking Reclast? *

What are other drugs people take besides Reclast? *

Restasis: 4 people, 21.05%
Synthroid: 4 people, 21.05%
Lyrica: 4 people, 21.05%
Topamax: 3 people, 15.79%
Cymbalta: 3 people, 15.79%
Omega-3 Marine Triglycerides: 3 people, 15.79%
Amitiza: 3 people, 15.79%
Fosamax: 3 people, 15.79%
Hydrochlorothiazide: 3 people, 15.79%
Norvasc: 2 people, 10.53%

What are other side effects people have besides Lymphoedema? *

Fall: 6 people, 31.58%
Oedema Peripheral (superficial swelling): 5 people, 26.32%
Peripheral Swelling: 4 people, 21.05%
Road Traffic Accident: 4 people, 21.05%
Hyperlipidaemia (presence of excess lipids in the blood): 4 people, 21.05%
Cellulitis (infection under the skin): 4 people, 21.05%
Cataract (clouding of the lens inside the eye): 4 people, 21.05%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 4 people, 21.05%
Fibromyalgia (a long-term condition which causes pain all over the body): 4 people, 21.05%
Spinal Osteoarthritis (joint cartilage loss in spine): 4 people, 21.05%

What are the existing conditions these people have? *

Vulvovaginal Dryness: 2 people, 10.53%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 2 people, 10.53%
High Blood Pressure: 2 people, 10.53%
Pain: 2 people, 10.53%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 2 people, 10.53%
Oedema Peripheral (superficial swelling): 2 people, 10.53%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 10.53%
Seasonal Allergy (allergic condition due to certain season): 2 people, 10.53%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 5.26%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Reclast and have Lymphoedema?

- Check whether Lymphoedema is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Reclast:

Reclast (15,774 reports)

Lymphoedema treatments and more:

Lymphoedema (9,453 reports)

Browse all side effects of Reclast:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Lymphoedema:

Lymphoedema (911 drugs)

Browse all the conditions that are associated with Lymphoedema:

Lymphoedema (743 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on zoledronic acid (the active ingredients of Reclast) and Reclast (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.