Reclast and Surgery - a phase IV clinical study of FDA data

Summary:

Surgery is reported as a side effect among people who take Reclast (zoledronic acid), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Fosamax, and have Cataplexy.

The phase IV clinical study analyzes which people have Surgery when taking Reclast. It is created by eHealthMe based on reports of 15,446 people who have side effects when taking Reclast from the FDA, and is updated regularly.

What is Reclast?

Reclast has active ingredients of zoledronic acid. It is often used in osteoporosis. eHealthMe is studying from 15,774 Reclast users. Check the latest studies of Reclast.

What is Surgery?

Surgery is found to be associated with 1,477 drugs and 1,248 conditions by eHealthMe. Check the latest studies of Surgery.

On Aug, 03, 2026

15,446 people reported to have side effects when taking Reclast.
Among them, 70 people (0.45%) have Surgery.

Among these 70 people:

How long have people been on Reclast when they have Surgery? *

What is the gender of people who have Surgery when taking Reclast? *

female: 98.51 %
male: 1.49 %

What is the age of people who have Surgery when taking Reclast? *

What are other drugs people take besides Reclast? *

What are other side effects people have besides Surgery? *

Pain In Extremity: 12 people, 17.14%
Joint Pain: 12 people, 17.14%
Femur Fracture: 11 people, 15.71%
Fall: 11 people, 15.71%
Rashes (redness): 10 people, 14.29%
High Blood Pressure: 8 people, 11.43%
Drug Ineffective: 8 people, 11.43%
Nausea (feeling of having an urge to vomit): 8 people, 11.43%
Fatigue (feeling of tiredness): 8 people, 11.43%
Cough: 8 people, 11.43%

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 11.43%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 11.43%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 8 people, 11.43%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 5.71%
High Blood Pressure: 3 people, 4.29%
Insomnia (sleeplessness): 3 people, 4.29%
Asthma: 2 people, 2.86%
Bone Density Decreased: 2 people, 2.86%
Bone Disorder: 2 people, 2.86%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 2 people, 2.86%

* Approximation only. Some reports may have incomplete information.

Do you take Reclast and have Surgery?

- Check whether Surgery is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Reclast:

Reclast (15,774 reports)

Surgery treatments and more:

Surgery (63,811 reports)

Browse all side effects of Reclast:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Surgery:

Surgery (1,477 drugs)

Browse all the conditions that are associated with Surgery:

Surgery (1,248 conditions)

Related publications that referenced our studies

Briggs P, Hawrylack H, Mooney R, "Inhaled peppermint oil for postop nausea in patients undergoing cardiac surgery", Nursing, 2016 Jul .
Mariappan R, Prasad A, Venkatraghavan L, "An uncommon cause for severe hypophosphataemia after transsphenoidal pituitary surgery", Journal of Neuroanaesthesiology and Critical Care, 2014 May .
Briggs P, Hawrylack H, Mooney R, "Inhaled peppermint oil for postop nausea in patients undergoing cardiac surgery", Nursing, 2016 Jul .
Mariappan R, Prasad A, Venkatraghavan L, "An uncommon cause for severe hypophosphataemia after transsphenoidal pituitary surgery", Journal of Neuroanaesthesiology and Critical Care, 2014 May .

How the study uses the data?

The study uses data from the FDA. It is based on zoledronic acid (the active ingredients of Reclast) and Reclast (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.