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Refludan and Heart attack - a phase IV clinical study of FDA data

Summary:

Heart attack is reported as a side effect among people who take Refludan (lepirudin recombinant), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Pepcid, and have Thrombocytopenia.

The phase IV clinical study analyzes which people have Heart attack when taking Refludan. It is created by eHealthMe based on reports of 539 people who have side effects when taking Refludan from the FDA, and is updated regularly.

What is Refludan?

Refludan has active ingredients of lepirudin recombinant. eHealthMe is studying from 540 Refludan users. Check the latest studies of Refludan.

What is Heart attack?

Heart attack is found to be associated with 2,484 drugs and 3,296 conditions by eHealthMe. Check the latest studies of Heart attack.

On Jul, 13, 2026

539 people reported to have side effects when taking Refludan.
Among them, 11 people (2.04%) have Heart attack.

Could Refludan cause Heart attack?

Among these 11 people:

How long have people been on Refludan when they have Heart attack? *

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Heart attack when taking Refludan? *

  • female: 63.64 %
  • male: 36.36 %

What is the age of people who have Heart attack when taking Refludan? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 9.09 %
  • 60+: 90.91 %

What are other drugs people take besides Refludan? *

  1. Pepcid: 3 people, 27.27%
  2. Prednisone: 2 people, 18.18%
  3. Neurontin: 2 people, 18.18%
  4. Midazolam Hydrochloride: 2 people, 18.18%
  5. Metoprolol Tartrate: 2 people, 18.18%
  6. Lopressor: 2 people, 18.18%
  7. Fentanyl: 2 people, 18.18%
  8. Zocor: 1 person, 9.09%
  9. Tricor: 1 person, 9.09%
  10. Orgaran: 1 person, 9.09%

What are other side effects people have besides Heart attack? *

  1. Rectal Haemorrhage (bleeding from anus): 4 people, 36.36%
  2. Peritoneal Haemorrhage (peritoneal bleeding): 4 people, 36.36%
  3. Nosebleed (bleeding from nose): 4 people, 36.36%
  4. Anaphylaxis (serious allergic reaction that is rapid in onset and may cause death): 3 people, 27.27%
  5. Faecal Occult Blood Positive: 2 people, 18.18%
  6. Gangrene (body tissue dies): 2 people, 18.18%
  7. Activated Partial Thromboplastin Time Prolonged: 2 people, 18.18%
  8. Ards (Acute Respiratory Distress Syndrome) (sudden failure of the respiratory (breathing) system): 2 people, 18.18%
  9. Bleeding Disorders: 2 people, 18.18%
  10. Consciousness - Decreased: 2 people, 18.18%

What are the existing conditions these people have? *

  1. Thrombocytopenia (decrease of platelets in blood): 4 people, 36.36%
  2. Heparin-Induced Thrombocytopenia: 2 people, 18.18%

* Approximation only. Some reports may have incomplete information.

Do you take Refludan and have Heart attack?

- Check whether Heart attack is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Refludan:

Heart attack treatments and more:

How severe was Heart attack and when was it recovered:

Expand to all the drugs that have ingredients of lepirudin recombinant:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Refludan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Heart attack:

Browse all the conditions that are associated with Heart attack:

How the study uses the data?

The study uses data from the FDA. It is based on lepirudin recombinant (the active ingredients of Refludan) and Refludan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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