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Reglan and Multiple sclerosis - a phase IV clinical study of FDA data

Summary:

Multiple sclerosis is reported as a side effect among people who take Reglan (metoclopramide hydrochloride), especially for people who are female, 50-59 old, have been taking the drug for 5 - 10 years also take Ambien, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Multiple sclerosis when taking Reglan. It is created by eHealthMe based on reports of 28,854 people who have side effects when taking Reglan from the FDA, and is updated regularly.

What is Reglan?

Reglan has active ingredients of metoclopramide hydrochloride. It is often used in gastroparesis. eHealthMe is studying from 29,455 Reglan users. Check the latest studies of Reglan.

What is Multiple sclerosis?

Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath) is found to be associated with 1,088 drugs and 1,358 conditions by eHealthMe. Check the latest studies of Multiple sclerosis.

On Jul, 04, 2026

28,854 people reported to have side effects when taking Reglan.
Among them, 88 people (0.3%) have Multiple sclerosis.

Could Reglan cause Multiple sclerosis?

Among these 88 people:

How long have people been on Reglan when they have Multiple sclerosis? *

  • < 1 month: 12.5 %
  • 1 - 6 months: 12.5 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 12.5 %
  • 5 - 10 years: 62.5 %
  • 10+ years: 0.0 %

What is the gender of people who have Multiple sclerosis when taking Reglan? *

  • female: 94.32 %
  • male: 5.68 %

What is the age of people who have Multiple sclerosis when taking Reglan? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 1.49 %
  • 30-39: 14.93 %
  • 40-49: 14.93 %
  • 50-59: 43.28 %
  • 60+: 25.37 %

What are other drugs people take besides Reglan? *

  1. Ambien: 28 people, 31.82%
  2. Protonix: 27 people, 30.68%
  3. Neurontin: 27 people, 30.68%
  4. Prozac: 23 people, 26.14%
  5. Celebrex: 21 people, 23.86%
  6. Prempro: 20 people, 22.73%
  7. Skelaxin: 20 people, 22.73%
  8. Vioxx: 19 people, 21.59%
  9. Pepcid: 19 people, 21.59%
  10. Plaquenil: 18 people, 20.45%

What are other side effects people have besides Multiple sclerosis? *

  1. Urinary Tract Infection: 26 people, 29.55%
  2. Back Pain: 24 people, 27.27%
  3. Weakness: 23 people, 26.14%
  4. Hypoaesthesia (reduced sense of touch or sensation): 22 people, 25.00%
  5. Muscle Spasms (muscle contraction): 22 people, 25.00%
  6. Joint Pain: 21 people, 23.86%
  7. Pain In Extremity: 21 people, 23.86%
  8. Neck Pain: 20 people, 22.73%
  9. Acute Kidney Failure: 20 people, 22.73%
  10. Swelling: 19 people, 21.59%

What are the existing conditions these people have? *

  1. Multiple Myeloma (cancer of the plasma cells): 17 people, 19.32%
  2. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 17 people, 19.32%
  3. Pain: 8 people, 9.09%
  4. Gait Disturbance: 7 people, 7.95%
  5. Seizures (abnormal excessive or synchronous neuronal activity in the brain): 4 people, 4.55%
  6. Muscle Spasms (muscle contraction): 4 people, 4.55%
  7. Neoplasm Malignant (cancer tumour): 4 people, 4.55%
  8. Wheezing (a high-pitched whistling sound made while you breath): 4 people, 4.55%
  9. Stress And Anxiety: 3 people, 3.41%
  10. Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 3 people, 3.41%

* Approximation only. Some reports may have incomplete information.

Do you take Reglan and have Multiple sclerosis?

- Check whether Multiple sclerosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Reglan:

Multiple sclerosis treatments and more:

How severe was Multiple sclerosis and when was it recovered:

Expand to all the drugs that have ingredients of metoclopramide hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Reglan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Multiple sclerosis:

Browse all the conditions that are associated with Multiple sclerosis:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on metoclopramide hydrochloride (the active ingredients of Reglan) and Reglan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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