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Renagel and Hyponatremia - a phase IV clinical study of FDA data

Summary:

Hyponatremia is reported as a side effect among people who take Renagel (sevelamer hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Plavix, and have High blood pressure.

The phase IV clinical study analyzes which people have Hyponatremia when taking Renagel. It is created by eHealthMe based on reports of 8,224 people who have side effects when taking Renagel from the FDA, and is updated regularly.

What is Renagel?

Renagel has active ingredients of sevelamer hydrochloride. eHealthMe is studying from 8,246 Renagel users. Check the latest studies of Renagel.

What is Hyponatremia?

Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration) is found to be associated with 1,941 drugs and 2,272 conditions by eHealthMe. Check the latest studies of Hyponatremia.

On Aug, 01, 2026

8,224 people reported to have side effects when taking Renagel.
Among them, 34 people (0.41%) have Hyponatremia.

Could Renagel cause Hyponatremia?

Among these 34 people:

How long have people been on Renagel when they have Hyponatremia? *

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Hyponatremia when taking Renagel? *

  • female: 69.7 %
  • male: 30.3 %

What is the age of people who have Hyponatremia when taking Renagel? *

  • 0-1: 3.23 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 3.23 %
  • 40-49: 0.0 %
  • 50-59: 29.03 %
  • 60+: 64.52 %

What are other drugs people take besides Renagel? *

  1. Plavix: 14 people, 41.18%
  2. Lasix: 9 people, 26.47%
  3. Aranesp: 6 people, 17.65%
  4. Levothyroxine Sodium: 5 people, 14.71%
  5. Norvasc: 5 people, 14.71%
  6. Rocaltrol: 5 people, 14.71%
  7. Omnicef: 5 people, 14.71%
  8. Synthroid: 5 people, 14.71%
  9. Nexium: 5 people, 14.71%
  10. Glyburide: 5 people, 14.71%

What are other side effects people have besides Hyponatremia? *

  1. Hypokalemia (low potassium): 14 people, 41.18%
  2. Fall: 10 people, 29.41%
  3. Nausea And Vomiting: 9 people, 26.47%
  4. Nausea (feeling of having an urge to vomit): 8 people, 23.53%
  5. Hypoglycemia (low blood sugar): 6 people, 17.65%
  6. Diabetes Mellitus Inadequate Control: 6 people, 17.65%
  7. Hyperkalemia (damage to or disease of the kidney): 6 people, 17.65%
  8. Chronic Renal Failure (kidney failure): 6 people, 17.65%
  9. Dyspnea (difficult or laboured breathing): 5 people, 14.71%
  10. Pneumonia: 5 people, 14.71%

What are the existing conditions these people have? *

  1. High Blood Pressure: 18 people, 52.94%
  2. Stress And Anxiety: 10 people, 29.41%
  3. Acute Coronary Syndrome (acute chest pain and other symptoms that happen because the heart does not get blood): 10 people, 29.41%
  4. Blood Phosphorus Increased: 10 people, 29.41%
  5. Dyslipidaemia (abnormal amount of lipids): 10 people, 29.41%
  6. Hypokalemia (low potassium): 10 people, 29.41%
  7. Hyperphosphataemia (electrolyte disturbance in which there is an abnormally elevated level of phosphate in the blood): 9 people, 26.47%
  8. Diarrhea: 4 people, 11.76%
  9. Gastritis - Chronic (long lasting inflammation of stomach): 4 people, 11.76%
  10. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 11.76%

* Approximation only. Some reports may have incomplete information.

Do you take Renagel and have Hyponatremia?

- Check whether Hyponatremia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Renagel:

Hyponatremia treatments and more:

How severe was Hyponatremia and when was it recovered:

Expand to all the drugs that have ingredients of sevelamer hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Renagel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyponatremia:

Browse all the conditions that are associated with Hyponatremia:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on sevelamer hydrochloride (the active ingredients of Renagel) and Renagel (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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