Repatha and Device failure - a phase IV clinical study of FDA data

Summary:

Device failure is reported as a side effect among people who take Repatha (evolocumab), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Plavix, and have Hyperlipidaemia.

The phase IV clinical study analyzes which people have Device failure when taking Repatha. It is created by eHealthMe based on reports of 155,838 people who have side effects when taking Repatha from the FDA, and is updated regularly.

What is Repatha?

Repatha has active ingredients of evolocumab. It is often used in high blood cholesterol. eHealthMe is studying from 156,232 Repatha users. Check the latest studies of Repatha.

What is Device failure?

Device failure is found to be associated with 824 drugs and 744 conditions by eHealthMe. Check the latest studies of Device failure.



On Nov, 22, 2025

155,838 people reported to have side effects when taking Repatha.
Among them, 209 people (0.13%) have Device failure.

Could Repatha cause Device failure?

Among these 209 people:

How long have people been on Repatha when they have Device failure? *

  • < 1 month: 50 %
  • 1 - 6 months: 50 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Device failure when taking Repatha? *

  • female: 56.31 %
  • male: 43.69 %

What is the age of people who have Device failure when taking Repatha? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.51 %
  • 40-49: 2.53 %
  • 50-59: 19.19 %
  • 60+: 77.78 %

What are other drugs people take besides Repatha? *

  1. Plavix: 4 people, 1.91%
  2. Trulicity: 3 people, 1.44%
  3. Prolia: 3 people, 1.44%
  4. Insulin: 3 people, 1.44%
  5. Levemir: 3 people, 1.44%
  6. Prasugrel: 2 people, 0.96%
  7. Zestril: 1 person, 0.48%
  8. Lexapro: 1 person, 0.48%
  9. Canasa: 1 person, 0.48%
  10. Cartia Xt: 1 person, 0.48%

What are other side effects people have besides Device failure? *

  1. Injection Site Pain: 18 people, 8.61%
  2. Injection Site Haemorrhage (bleeding from injection site): 15 people, 7.18%
  3. Injection Site Bruising: 9 people, 4.31%
  4. Injection Site Erythema (redness at injection site): 5 people, 2.39%
  5. Injection Site Swelling: 5 people, 2.39%
  6. Anaemia (lack of blood): 4 people, 1.91%
  7. Sleep Disorder: 4 people, 1.91%
  8. Back Pain: 3 people, 1.44%
  9. Cardiac Failure Congestive: 3 people, 1.44%
  10. Cough: 3 people, 1.44%

What are the existing conditions these people have? *

  1. Hyperlipidaemia (presence of excess lipids in the blood): 14 people, 6.70%
  2. Dyslipidaemia (abnormal amount of lipids): 5 people, 2.39%
  3. Diabetes: 4 people, 1.91%
  4. Lipids Abnormal: 2 people, 0.96%
  5. Heart Disease: 2 people, 0.96%
  6. Cardiac Disorder: 2 people, 0.96%
  7. Type 1 Diabetes: 1 person, 0.48%
  8. Low Density Lipoprotein Decreased (cholesterol decreased): 1 person, 0.48%
  9. Insomnia (sleeplessness): 1 person, 0.48%
  10. Hypotension (abnormally low blood pressure): 1 person, 0.48%

* Approximation only. Some reports may have incomplete information.

Do you take Repatha and have Device failure?

- Check whether Device failure is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Repatha:

Device failure treatments and more:

How severe was Device failure and when was it recovered:

Expand to all the drugs that have ingredients of evolocumab:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Common Repatha side effects:

Browse all side effects of Repatha:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Device failure:

Browse all the drugs that are associated with Device failure:

Common conditions associated with Device failure:

Browse all the conditions that are associated with Device failure:

Drugs similar to Repatha and Device failure :


How the study uses the data?

The study uses data from the FDA. It is based on evolocumab (the active ingredients of Repatha) and Repatha (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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