Repatha and Lipids increased - a phase IV clinical study of FDA data

Summary:

Lipids increased is reported as a side effect among people who take Repatha (evolocumab), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Synthroid, and have Muscle aches.

The phase IV clinical study analyzes which people have Lipids increased when taking Repatha. It is created by eHealthMe based on reports of 155,838 people who have side effects when taking Repatha from the FDA, and is updated regularly.

What is Repatha?

Repatha has active ingredients of evolocumab. It is often used in high blood cholesterol. eHealthMe is studying from 156,258 Repatha users. Check the latest studies of Repatha.

What is Lipids increased?

Lipids increased (excess lipid in body) is found to be associated with 325 drugs and 365 conditions by eHealthMe. Check the latest studies of Lipids increased.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

155,838 people reported to have side effects when taking Repatha.
Among them, 62 people (0.04%) have Lipids increased.

Among these 62 people:

How long have people been on Repatha when they have Lipids increased? *

What is the gender of people who have Lipids increased when taking Repatha? *

female: 70.18 %
male: 29.82 %

What is the age of people who have Lipids increased when taking Repatha? *

What are other drugs people take besides Repatha? *

What are other side effects people have besides Lipids increased? *

Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 14 people, 22.58%
Muscle Aches (muscle pain): 14 people, 22.58%
Abdominal Discomfort: 12 people, 19.35%
Therapeutic Response Decreased (less preventive response): 12 people, 19.35%
Basedow's Disease (autoimmune disease where the thyroid is overactive, producing an excessive amount of thyroid hormones): 12 people, 19.35%
Joint Pain: 5 people, 8.06%
Back Pain: 4 people, 6.45%
Malaise (a feeling of general discomfort or uneasiness): 4 people, 6.45%
Ill-Defined Disorder: 3 people, 4.84%
Low Density Lipoprotein Increased (cholesterol increased in blood): 3 people, 4.84%

What are the existing conditions these people have? *

Muscle Aches (muscle pain): 11 people, 17.74%
Hyperlipidaemia (presence of excess lipids in the blood): 5 people, 8.06%
Low Density Lipoprotein Increased (cholesterol increased in blood): 1 person, 1.61%
Diabetes: 1 person, 1.61%
Cardiac Disorder: 1 person, 1.61%

* Approximation only. Some reports may have incomplete information.

Do you take Repatha and have Lipids increased?

- Check whether Lipids increased is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Repatha:

Repatha (156,258 reports)

Browse all side effects of Repatha:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Lipids increased:

Lipids increased (325 drugs)

Browse all the conditions that are associated with Lipids increased:

Lipids increased (365 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on evolocumab (the active ingredients of Repatha) and Repatha (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.