Repatha and Orthostatic hypotension - a phase IV clinical study of FDA data

Summary:

Orthostatic hypotension is reported as a side effect among people who take Repatha (evolocumab), especially for people who are male, 60+ old, have been taking the drug for 1 - 6 months also take Tylenol, and have Hyperlipidaemia.

The phase IV clinical study analyzes which people have Orthostatic hypotension when taking Repatha. It is created by eHealthMe based on reports of 155,838 people who have side effects when taking Repatha from the FDA, and is updated regularly.

What is Repatha?

Repatha has active ingredients of evolocumab. It is often used in high blood cholesterol. eHealthMe is studying from 156,258 Repatha users. Check the latest studies of Repatha.

What is Orthostatic hypotension?

Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up) is found to be associated with 1,232 drugs and 1,336 conditions by eHealthMe. Check the latest studies of Orthostatic hypotension.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

155,838 people reported to have side effects when taking Repatha.
Among them, 26 people (0.02%) have Orthostatic hypotension.

Could Repatha cause Orthostatic hypotension?

Among these 26 people:

How long have people been on Repatha when they have Orthostatic hypotension? *

What is the gender of people who have Orthostatic hypotension when taking Repatha? *

female: 37.5 %
male: 62.5 %

What is the age of people who have Orthostatic hypotension when taking Repatha? *

What are other drugs people take besides Repatha? *

What are other side effects people have besides Orthostatic hypotension? *

Weakness: 10 people, 38.46%
Pulmonary Embolism (blockage of the main artery of the lung): 10 people, 38.46%
Fall: 10 people, 38.46%
Fatigue (feeling of tiredness): 9 people, 34.62%
Herpes Zoster: 8 people, 30.77%
Post Herpetic Neuralgia (neuralgia caused by the varicella zoster virus): 8 people, 30.77%
Post Procedural Swelling: 8 people, 30.77%
Actinic Keratosis (skin disease due to sun exposure): 8 people, 30.77%
High Blood Pressure: 7 people, 26.92%
Back Pain: 6 people, 23.08%

What are the existing conditions these people have? *

Hyperlipidaemia (presence of excess lipids in the blood): 6 people, 23.08%
High Blood Pressure: 3 people, 11.54%
Dyslipidaemia (abnormal amount of lipids): 3 people, 11.54%
Pain: 2 people, 7.69%
Psoriasis (immune-mediated disease that affects the skin): 1 person, 3.85%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 1 person, 3.85%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 3.85%
Multiple Myeloma (cancer of the plasma cells): 1 person, 3.85%
Metastases To Bone (cancer spreads to bone): 1 person, 3.85%
Diabetes: 1 person, 3.85%

* Approximation only. Some reports may have incomplete information.

Do you take Repatha and have Orthostatic hypotension?

- Check whether Orthostatic hypotension is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Repatha:

Repatha (156,258 reports)

Browse all side effects of Repatha:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Orthostatic hypotension:

Orthostatic hypotension (1,232 drugs)

Browse all the conditions that are associated with Orthostatic hypotension:

Orthostatic hypotension (1,336 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on evolocumab (the active ingredients of Repatha) and Repatha (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.