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Repatha and Spinal stenosis - a phase IV clinical study of FDA data

Summary:

Spinal stenosis is reported as a side effect among people who take Repatha (evolocumab), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Brilinta, and have Cardiac disorder.

The phase IV clinical study analyzes which people have Spinal stenosis when taking Repatha. It is created by eHealthMe based on reports of 155,838 people who have side effects when taking Repatha from the FDA, and is updated regularly.

What is Repatha?

Repatha has active ingredients of evolocumab. It is often used in high blood cholesterol. eHealthMe is studying from 156,258 Repatha users. Check the latest studies of Repatha.

What is Spinal stenosis?

Spinal stenosis (narrowing of spinal column) is found to be associated with 503 drugs and 206 conditions by eHealthMe. Check the latest studies of Spinal stenosis.

On Aug, 12, 2026

155,838 people reported to have side effects when taking Repatha.
Among them, 29 people (0.02%) have Spinal stenosis.

Could Repatha cause Spinal stenosis?

Among these 29 people:

How long have people been on Repatha when they have Spinal stenosis? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 50 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 50 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Spinal stenosis when taking Repatha? *

  • female: 68.75 %
  • male: 31.25 %

What is the age of people who have Spinal stenosis when taking Repatha? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 10 %
  • 50-59: 10 %
  • 60+: 80 %

What are other drugs people take besides Repatha? *

  1. Vitamin B12: 2 people, 6.90%
  2. Fish Oil: 2 people, 6.90%
  3. Coenzyme Q10: 2 people, 6.90%
  4. Brilinta: 2 people, 6.90%
  5. Vistaril: 1 person, 3.45%
  6. Tylenol: 1 person, 3.45%
  7. Topamax: 1 person, 3.45%
  8. Lipitor: 1 person, 3.45%
  9. Gabapentin: 1 person, 3.45%
  10. Cymbalta: 1 person, 3.45%

What are other side effects people have besides Spinal stenosis? *

  1. Disability: 5 people, 17.24%
  2. Presyncope: 2 people, 6.90%
  3. Diarrhea: 2 people, 6.90%
  4. Hypoacusis (loss of hearing): 2 people, 6.90%
  5. Weight Decreased: 2 people, 6.90%
  6. Muscle Spasms (muscle contraction): 2 people, 6.90%
  7. Musculoskeletal Stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 2 people, 6.90%
  8. Osteoarthritis (a joint disease caused by cartilage loss in a joint): 2 people, 6.90%
  9. Headache (pain in head): 2 people, 6.90%
  10. Rhinorrhea (watery mucus discharge from the nose): 2 people, 6.90%

What are the existing conditions these people have? *

  1. Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 6.90%
  2. Cardiac Disorder: 2 people, 6.90%
  3. Tinnitus (a ringing in the ears): 1 person, 3.45%
  4. Sleep Disorder: 1 person, 3.45%
  5. Pain: 1 person, 3.45%
  6. Neuralgia (pain in one or more nerves): 1 person, 3.45%

* Approximation only. Some reports may have incomplete information.

Do you take Repatha and have Spinal stenosis?

- Check whether Spinal stenosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Repatha:

Spinal stenosis treatments and more:

How severe was Spinal stenosis and when was it recovered:

Expand to all the drugs that have ingredients of evolocumab:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Repatha:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Spinal stenosis:

Browse all the conditions that are associated with Spinal stenosis:

How the study uses the data?

The study uses data from the FDA. It is based on evolocumab (the active ingredients of Repatha) and Repatha (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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