Repatha and Temperature intolerance - a phase IV clinical study of FDA data

Summary:

Temperature intolerance is reported as a side effect among people who take Repatha (evolocumab), especially for people who are male, 60+ old, have been taking the drug for 1 - 2 years also take Magnesium, and have Hyperlipidaemia.

The phase IV clinical study analyzes which people have Temperature intolerance when taking Repatha. It is created by eHealthMe based on reports of 155,838 people who have side effects when taking Repatha from the FDA, and is updated regularly.

What is Repatha?

Repatha has active ingredients of evolocumab. It is often used in high blood cholesterol. eHealthMe is studying from 156,258 Repatha users. Check the latest studies of Repatha.

What is Temperature intolerance?

Temperature intolerance (inability to go in temperature) is found to be associated with 818 drugs and 754 conditions by eHealthMe. Check the latest studies of Temperature intolerance.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 22, 2026

155,838 people reported to have side effects when taking Repatha.
Among them, 29 people (0.02%) have Temperature intolerance.

Could Repatha cause Temperature intolerance?

Among these 29 people:

How long have people been on Repatha when they have Temperature intolerance? *

What is the gender of people who have Temperature intolerance when taking Repatha? *

female: 37.93 %
male: 62.07 %

What is the age of people who have Temperature intolerance when taking Repatha? *

What are other drugs people take besides Repatha? *

Magnesium: 5 people, 17.24%
Zyrtec: 2 people, 6.90%
Amlodipine: 2 people, 6.90%
Humira: 2 people, 6.90%
Fish Oil: 2 people, 6.90%
Brilinta: 2 people, 6.90%
Potassium: 2 people, 6.90%
Cymbalta: 1 person, 3.45%
Inderal: 1 person, 3.45%
Hydrocodone Bitartrate And Acetaminophen: 1 person, 3.45%

What are other side effects people have besides Temperature intolerance? *

Dizziness: 9 people, 31.03%
Fatigue (feeling of tiredness): 7 people, 24.14%
Joint Pain: 6 people, 20.69%
Weakness: 6 people, 20.69%
Feeling Abnormal: 5 people, 17.24%
Sunburn: 4 people, 13.79%
Cough: 4 people, 13.79%
Dyspnea Exertional: 4 people, 13.79%
Muscle Aches (muscle pain): 4 people, 13.79%
Oropharyngeal Pain: 4 people, 13.79%

What are the existing conditions these people have? *

Hyperlipidaemia (presence of excess lipids in the blood): 5 people, 17.24%
Low Density Lipoprotein Increased (cholesterol increased in blood): 3 people, 10.34%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 6.90%
Blood Uric Acid Abnormal: 2 people, 6.90%
Muscle Spasms (muscle contraction): 2 people, 6.90%
High Blood Pressure: 2 people, 6.90%
Hypertriglyceridaemia (excess of triglycerides in the blood): 1 person, 3.45%
Chronic Thyroiditis (long lasting inflammation of thyroid gland): 1 person, 3.45%
Drowsiness: 1 person, 3.45%
Wheezing (a high-pitched whistling sound made while you breath): 1 person, 3.45%

* Approximation only. Some reports may have incomplete information.

Do you take Repatha and have Temperature intolerance?

- Check whether Temperature intolerance is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Repatha:

Repatha (156,258 reports)

Browse all side effects of Repatha:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Temperature intolerance:

Temperature intolerance (818 drugs)

Browse all the conditions that are associated with Temperature intolerance:

Temperature intolerance (754 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on evolocumab (the active ingredients of Repatha) and Repatha (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.