Requip and Sleeping difficulty - a phase IV clinical study of FDA data

Summary:

Sleeping difficulty is reported as a side effect among people who take Requip (ropinirole hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Lyrica, and have Depression.

The phase IV clinical study analyzes which people have Sleeping difficulty when taking Requip. It is created by eHealthMe based on reports of 21,866 people who have side effects when taking Requip from the FDA, and is updated regularly.

What is Requip?

Requip has active ingredients of ropinirole hydrochloride. It is often used in restless leg syndrome. eHealthMe is studying from 22,949 Requip users. Check the latest studies of Requip.

What is Sleeping difficulty?

Sleeping difficulty (difficult sleeping) is found to be associated with 4,213 drugs and 5,350 conditions by eHealthMe. Check the latest studies of Sleeping difficulty.

On Nov, 24, 2025

21,866 people reported to have side effects when taking Requip.
Among them, 1,008 people (4.61%) have Sleeping difficulty.

Among these 1,008 people:

How long have people been on Requip when they have Sleeping difficulty? *

What is the gender of people who have Sleeping difficulty when taking Requip? *

female: 66.08 %
male: 33.92 %

What is the age of people who have Sleeping difficulty when taking Requip? *

What are other drugs people take besides Requip? *

What are other side effects people have besides Sleeping difficulty? *

Fatigue (feeling of tiredness): 187 people, 18.55%
Stress And Anxiety: 184 people, 18.25%
Nausea (feeling of having an urge to vomit): 172 people, 17.06%
Pain: 166 people, 16.47%
Drug Ineffective: 158 people, 15.67%
Drowsiness: 142 people, 14.09%
Dizziness: 136 people, 13.49%
Depression: 125 people, 12.40%
Gait Disturbance: 114 people, 11.31%
Muscle Spasms (muscle contraction): 110 people, 10.91%

What are the existing conditions these people have? *

Depression: 84 people, 8.33%
Pain: 70 people, 6.94%
Sleep Disorder: 63 people, 6.25%
High Blood Pressure: 47 people, 4.66%
Stress And Anxiety: 44 people, 4.37%
High Blood Cholesterol: 40 people, 3.97%
Neuropathy Peripheral (surface nerve damage): 33 people, 3.27%
Muscle Spasms (muscle contraction): 33 people, 3.27%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 31 people, 3.08%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 27 people, 2.68%

* Approximation only. Some reports may have incomplete information.

Do you take Requip and have Sleeping difficulty?

- Check whether Sleeping difficulty is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Requip:

Requip (22,949 reports)

Common Requip side effects:

Browse all side effects of Requip:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Sleeping difficulty:

Browse all the drugs that are associated with Sleeping difficulty:

Sleeping difficulty (4,213 drugs)

Common conditions associated with Sleeping difficulty:

Depression: 17,540 reports
Antidepressant therapy: 17,500 reports
Pain: 13,668 reports
Arthritis - rheumatoid: 13,625 reports
Hypnosis and pain: 13,485 reports
Multiple sclerosis aggravated: 12,998 reports
Hypertension aggravated: 12,107 reports
High blood pressure: 12,061 reports
Anxiety: 10,449 reports
Stress and anxiety: 10,431 reports

Browse all the conditions that are associated with Sleeping difficulty:

Sleeping difficulty (5,350 conditions)

Drugs similar to Requip and Sleeping difficulty :

How the study uses the data?

The study uses data from the FDA. It is based on ropinirole hydrochloride (the active ingredients of Requip) and Requip (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.