Restoril and Application site erythema - a phase IV clinical study of FDA data

Summary:

Application site erythema is reported as a side effect among people who take Restoril (temazepam), especially for people who are female, 50-59 old, also take Prevacid, and have Headache.

The phase IV clinical study analyzes which people have Application site erythema when taking Restoril. It is created by eHealthMe based on reports of 12,884 people who have side effects when taking Restoril from the FDA, and is updated regularly.

What is Restoril?

Restoril has active ingredients of temazepam. It is often used in insomnia. eHealthMe is studying from 13,522 Restoril users. Check the latest studies of Restoril.

What is Application site erythema?

Application site erythema (redness of the skin at application site) is found to be associated with 668 drugs and 950 conditions by eHealthMe. Check the latest studies of Application site erythema.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

12,884 people reported to have side effects when taking Restoril.
Among them, 16 people (0.12%) have Application site erythema.

Could Restoril cause Application site erythema?

Among these 16 people:

What is the gender of people who have Application site erythema when taking Restoril? *

female: 81.25 %
male: 18.75 %

What is the age of people who have Application site erythema when taking Restoril? *

What are other drugs people take besides Restoril? *

What are other side effects people have besides Application site erythema? *

Application Site Pruritus (application site severe itching of the skin): 10 people, 62.50%
Headache (pain in head): 5 people, 31.25%
High Blood Pressure: 5 people, 31.25%
Viral Infection: 5 people, 31.25%
Road Traffic Accident: 4 people, 25.00%
Complex Regional Pain Syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet)): 4 people, 25.00%
Herpes Zoster: 4 people, 25.00%
Drug Ineffective: 4 people, 25.00%
Tendon Injury: 3 people, 18.75%
Application Site Inflammation: 2 people, 12.50%

What are the existing conditions these people have? *

Headache (pain in head): 6 people, 37.50%
High Blood Pressure: 5 people, 31.25%
Stress And Anxiety: 5 people, 31.25%
Constipation: 5 people, 31.25%
Impaired Gastric Emptying: 5 people, 31.25%
Depression: 3 people, 18.75%
Norepinephrine Increased (excess level of norepinephrine): 3 people, 18.75%
Macular Degeneration (painless eye condition that leads to the gradual loss of central vision): 2 people, 12.50%
Hiatal Hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 2 people, 12.50%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 2 people, 12.50%

* Approximation only. Some reports may have incomplete information.

Do you take Restoril and have Application site erythema?

- Check whether Application site erythema is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Restoril:

Restoril (13,522 reports)

Browse all side effects of Restoril:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Application site erythema:

Application site erythema (668 drugs)

Browse all the conditions that are associated with Application site erythema:

Application site erythema (950 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on temazepam (the active ingredients of Restoril) and Restoril (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.