Retin-a and Aseptic necrosis - a phase IV clinical study of FDA data

Summary:

Aseptic necrosis is reported as a side effect among people who take Retin-a (tretinoin), especially for people who are female, 50-59 old, also take Celebrex, and have Osteoporosis.

The phase IV clinical study analyzes which people have Aseptic necrosis when taking Retin-a. It is created by eHealthMe based on reports of 2,373 people who have side effects when taking Retin-a from the FDA, and is updated regularly.

What is Retin-a?

Retin-a has active ingredients of tretinoin. It is often used in acne. eHealthMe is studying from 2,475 Retin-a users. Check the latest studies of Retin-a.

What is Aseptic necrosis?

Aseptic necrosis (the death of bone tissue due to a lack of blood supply) is found to be associated with 1,347 drugs and 1,691 conditions by eHealthMe. Check the latest studies of Aseptic necrosis.

On Jul, 05, 2026

2,373 people reported to have side effects when taking Retin-a.
Among them, 30 people (1.26%) have Aseptic necrosis.

Among these 30 people:

What is the gender of people who have Aseptic necrosis when taking Retin-a? *

female: 100 %
male: 0.0 %

What is the age of people who have Aseptic necrosis when taking Retin-a? *

What are other drugs people take besides Retin-a? *

What are other side effects people have besides Aseptic necrosis? *

Back Pain: 19 people, 63.33%
Scoliosis (a medical condition in which a person's spine is curved from side to side): 16 people, 53.33%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 16 people, 53.33%
Joint Pain: 16 people, 53.33%
Fatigue (feeling of tiredness): 16 people, 53.33%
Gait Disturbance: 16 people, 53.33%
Lung Neoplasm (tumour of lung): 15 people, 50.00%
Osteomyelitis (infection of bone): 15 people, 50.00%
Acute Kidney Failure: 15 people, 50.00%
Bone Lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries): 15 people, 50.00%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 14 people, 46.67%
Bone Density Decreased: 7 people, 23.33%
Bone Loss: 4 people, 13.33%
Osteopenia (a condition where bone mineral density is lower than normal): 3 people, 10.00%
Hypersensitivity: 3 people, 10.00%
Hiv Infection: 2 people, 6.67%
Metastases To Bone (cancer spreads to bone): 1 person, 3.33%
Back Pain: 1 person, 3.33%

* Approximation only. Some reports may have incomplete information.

Do you take Retin-a and have Aseptic necrosis?

- Check whether Aseptic necrosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Retin-a:

Retin-a (2,475 reports)

Aseptic necrosis treatments and more:

Aseptic necrosis (59,829 reports)

Browse all side effects of Retin-a:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Aseptic necrosis:

Aseptic necrosis (1,347 drugs)

Browse all the conditions that are associated with Aseptic necrosis:

Aseptic necrosis (1,691 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on tretinoin (the active ingredients of Retin-a) and Retin-a (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.