Rezulin and Oedema lower limb - a phase IV clinical study of FDA data

Summary:

Oedema lower limb is reported as a side effect among people who take Rezulin (troglitazone), especially for people who are female, 60+ old, have been taking the drug for 1 - 2 years also take Lasix, and have Type 2 diabetes.

The phase IV clinical study analyzes which people have Oedema lower limb when taking Rezulin. It is created by eHealthMe based on reports of 8,761 people who have side effects when taking Rezulin from the FDA, and is updated regularly.

What is Rezulin?

Rezulin has active ingredients of troglitazone. eHealthMe is studying from 8,764 Rezulin users. Check the latest studies of Rezulin.

What is Oedema lower limb?

Oedema lower limb (fluid collection in tissue of lower leg) is found to be associated with 652 drugs and 184 conditions by eHealthMe. Check the latest studies of Oedema lower limb.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

8,761 people reported to have side effects when taking Rezulin.
Among them, 470 people (5.36%) have Oedema lower limb.

Among these 470 people:

* Approximation only. Some reports may have incomplete information.

Do you take Rezulin and have Oedema lower limb?

- Check whether Oedema lower limb is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Rezulin:

Rezulin (8,764 reports)

Oedema lower limb treatments and more:

Oedema lower limb (11,620 reports)

How severe was Oedema lower limb and when was it recovered:

Oedema lower limb in Rezulin

Expand to all the drugs that have ingredients of troglitazone:

Oedema lower limb and drugs with ingredients of troglitazone (482 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Rezulin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Oedema lower limb:

Oedema lower limb (652 drugs)

Browse all the conditions that are associated with Oedema lower limb:

Oedema lower limb (184 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on troglitazone (the active ingredients of Rezulin) and Rezulin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.