Riociguat and Cardiac failure - a phase IV clinical study of FDA data

Summary:

Cardiac failure is reported as a side effect among people who take Riociguat (riociguat), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Opsumit, and have Primary pulmonary hypertension.

The phase IV clinical study analyzes which people have Cardiac failure when taking Riociguat. It is created by eHealthMe based on reports of 2,578 people who have side effects when taking Riociguat from the FDA, and is updated regularly.

What is Riociguat?

Riociguat has active ingredients of riociguat. eHealthMe is studying from 2,582 Riociguat users. Check the latest studies of Riociguat.

What is Cardiac failure?

Cardiac failure is found to be associated with 2,056 drugs and 2,212 conditions by eHealthMe. Check the latest studies of Cardiac failure.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

2,578 people reported to have side effects when taking Riociguat.
Among them, 82 people (3.18%) have Cardiac failure.

Among these 82 people:

How long have people been on Riociguat when they have Cardiac failure? *

What is the gender of people who have Cardiac failure when taking Riociguat? *

female: 64.94 %
male: 35.06 %

What is the age of people who have Cardiac failure when taking Riociguat? *

What are other drugs people take besides Riociguat? *

What are other side effects people have besides Cardiac failure? *

Fluid Retention (an abnormal accumulation of fluid in the blood): 20 people, 24.39%
Dyspnea (difficult or laboured breathing): 19 people, 23.17%
Hypotension (abnormally low blood pressure): 14 people, 17.07%
Fainting (loss of consciousness and postural tone): 12 people, 14.63%
Nausea (feeling of having an urge to vomit): 12 people, 14.63%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 12 people, 14.63%
Dizziness: 11 people, 13.41%
Diarrhea: 11 people, 13.41%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 11 people, 13.41%
Oedema Peripheral (superficial swelling): 11 people, 13.41%

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 58 people, 70.73%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 25 people, 30.49%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 4 people, 4.88%
Multiple Myeloma (cancer of the plasma cells): 4 people, 4.88%
Pain: 3 people, 3.66%
Type 2 Diabetes: 3 people, 3.66%
Oedema (fluid collection in tissue): 2 people, 2.44%
Gout (uric acid crystals building up in the body): 2 people, 2.44%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 2 people, 2.44%
Left Ventricular Dysfunction: 2 people, 2.44%

* Approximation only. Some reports may have incomplete information.

Do you take Riociguat and have Cardiac failure?

- Check whether Cardiac failure is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Riociguat:

Riociguat (2,582 reports)

Cardiac failure treatments and more:

Cardiac failure (147,157 reports)

Browse all side effects of Riociguat:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Cardiac failure:

Cardiac failure (2,056 drugs)

Browse all the conditions that are associated with Cardiac failure:

Cardiac failure (2,212 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on riociguat (the active ingredients of Riociguat) and Riociguat (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.