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Risperdal and Lupus-like syndrome - a phase IV clinical study of FDA data

Summary:

Lupus-like syndrome is reported as a side effect among people who take Risperdal (risperidone), especially for people who are female, 30-39 old, also take Clonazepam, and have Motormental retardation.

The phase IV clinical study analyzes which people have Lupus-like syndrome when taking Risperdal. It is created by eHealthMe based on reports of 126,253 people who have side effects when taking Risperdal from the FDA, and is updated regularly.

What is Risperdal?

Risperdal has active ingredients of risperidone. It is often used in bipolar disorder. eHealthMe is studying from 127,729 Risperdal users. Check the latest studies of Risperdal.

What is Lupus-like syndrome?

Lupus-like syndrome (a disease symptom matches with lupus an immune disease) is found to be associated with 405 drugs and 592 conditions by eHealthMe. Check the latest studies of Lupus-like syndrome.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

126,253 people reported to have side effects when taking Risperdal.
Among them, 12 people (0.01%) have Lupus-like syndrome.

Could Risperdal cause Lupus-like syndrome?

Among these 12 people:

What is the gender of people who have Lupus-like syndrome when taking Risperdal? *

  • female: 87.5 %
  • male: 12.5 %

What is the age of people who have Lupus-like syndrome when taking Risperdal? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 33.33 %
  • 20-29: 33.33 %
  • 30-39: 33.33 %
  • 40-49: 0.0 %
  • 50-59: 0.0 %
  • 60+: 0.0 %

What are other drugs people take besides Risperdal? *

  1. Zyprexa: 1 person, 8.33%
  2. Clonazepam: 1 person, 8.33%

What are other side effects people have besides Lupus-like syndrome? *

  1. Toxic Encephalopathy (a degenerative neurologic disorder caused by exposure to toxic substances): 1 person, 8.33%
  2. Thyroid Diseases: 1 person, 8.33%
  3. Tardive Dyskinesia (a disorder that involves involuntary movements): 1 person, 8.33%
  4. Splenomegaly (enlargement of spleen): 1 person, 8.33%
  5. Renal Injury (kidney injury): 1 person, 8.33%
  6. Pituitary Tumor Benign: 1 person, 8.33%
  7. Pericardial Effusion (fluid around the heart): 1 person, 8.33%
  8. Joint Pain: 1 person, 8.33%
  9. Iron Deficiency: 1 person, 8.33%
  10. Hiatal Hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 1 person, 8.33%

What are the existing conditions these people have? *

  1. Psychotic Disorder: 1 person, 8.33%
  2. Psoriasis (immune-mediated disease that affects the skin): 1 person, 8.33%
  3. Motormental Retardation (a slowing-down of thought and a reduction of physical work): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Risperdal and have Lupus-like syndrome?

- Check whether Lupus-like syndrome is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Risperdal:

Lupus-like syndrome treatments and more:

How severe was Lupus-like syndrome and when was it recovered:

Expand to all the drugs that have ingredients of risperidone:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Risperdal:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Lupus-like syndrome:

Browse all the conditions that are associated with Lupus-like syndrome:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on risperidone (the active ingredients of Risperdal) and Risperdal (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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