Rocephin and Bone marrow depression - a phase IV clinical study of FDA data

Summary:

Bone marrow depression is reported as a side effect among people who take Rocephin (ceftriaxone sodium), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Methotrexate, and have Fever.

The phase IV clinical study analyzes which people have Bone marrow depression when taking Rocephin. It is created by eHealthMe based on reports of 15,458 people who have side effects when taking Rocephin from the FDA, and is updated regularly.

What is Rocephin?

Rocephin has active ingredients of ceftriaxone sodium. It is often used in infection. eHealthMe is studying from 15,665 Rocephin users. Check the latest studies of Rocephin.

What is Bone marrow depression?

Bone marrow depression (decreased ability or inability of the bone marrow to produce blood cells) is found to be associated with 351 drugs and 465 conditions by eHealthMe. Check the latest studies of Bone marrow depression.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 15, 2026

15,458 people reported to have side effects when taking Rocephin.
Among them, 48 people (0.31%) have Bone marrow depression.

Could Rocephin cause Bone marrow depression?

Among these 48 people:

How long have people been on Rocephin when they have Bone marrow depression? *

What is the gender of people who have Bone marrow depression when taking Rocephin? *

female: 58.33 %
male: 41.67 %

What is the age of people who have Bone marrow depression when taking Rocephin? *

What are other drugs people take besides Rocephin? *

What are other side effects people have besides Bone marrow depression? *

Fever: 22 people, 45.83%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 11 people, 22.92%
Thrombocytopenia (decrease of platelets in blood): 9 people, 18.75%
Sepsis (a severe blood infection that can lead to organ failure and death): 7 people, 14.58%
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 7 people, 14.58%
Aspergillosis (an infection caused by a fungus called aspergillus): 6 people, 12.50%
Mouth Ulcers: 6 people, 12.50%
Cough: 5 people, 10.42%
Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 5 people, 10.42%
Haemoglobin Decreased: 5 people, 10.42%

What are the existing conditions these people have? *

Fever: 3 people, 6.25%
Disseminated Intravascular Coagulation (systemic activation of blood coagulation): 2 people, 4.17%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 2 people, 4.17%
Sepsis (a severe blood infection that can lead to organ failure and death): 1 person, 2.08%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 2.08%
Nocardia Infection (a bacterial infection that usually starts in the lungs. it may spread to other organ systems): 1 person, 2.08%
Lung Disorder (lung disease): 1 person, 2.08%
Ill-Defined Disorder: 1 person, 2.08%

* Approximation only. Some reports may have incomplete information.

Do you take Rocephin and have Bone marrow depression?

- Check whether Bone marrow depression is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Rocephin:

Rocephin (15,665 reports)

Browse all side effects of Rocephin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Bone marrow depression:

Bone marrow depression (351 drugs)

Browse all the conditions that are associated with Bone marrow depression:

Bone marrow depression (465 conditions)

Related publications that referenced our studies

Agrawal SR, Rajput A, Jain AP, "Leukocytoclastic vasculitis and acute allergic interstitial nephritis following ceftriaxone exposure", Journal of pharmacology & pharmacotherapeutics, 2014 Jan .
Agrawal SR, Rajput A, Jain AP, "Leukocytoclastic vasculitis and acute allergic interstitial nephritis following ceftriaxone exposure", Journal of pharmacology & pharmacotherapeutics, 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on ceftriaxone sodium (the active ingredients of Rocephin) and Rocephin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.