Rocephin and C. diff - a phase IV clinical study of FDA data

Summary:

C. diff is reported as a side effect among people who take Rocephin (ceftriaxone sodium), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Flagyl, and have High blood pressure.

The phase IV clinical study analyzes which people have C. diff when taking Rocephin. It is created by eHealthMe based on reports of 15,458 people who have side effects when taking Rocephin from the FDA, and is updated regularly.

What is Rocephin?

Rocephin has active ingredients of ceftriaxone sodium. It is often used in infection. eHealthMe is studying from 15,665 Rocephin users. Check the latest studies of Rocephin.

What is C. diff?

C. diff is found to be associated with 1,570 drugs and 1,777 conditions by eHealthMe. Check the latest studies of C. diff.

On Apr, 25, 2026

15,458 people reported to have side effects when taking Rocephin.
Among them, 130 people (0.84%) have C. diff.

Among these 130 people:

How long have people been on Rocephin when they have C. diff? *

What is the gender of people who have C. diff when taking Rocephin? *

female: 78.29 %
male: 21.71 %

What is the age of people who have C. diff when taking Rocephin? *

What are other drugs people take besides Rocephin? *

What are other side effects people have besides C. diff? *

Fever: 31 people, 23.85%
Dehydration (dryness resulting from the removal of water): 28 people, 21.54%
Anaemia (lack of blood): 27 people, 20.77%
Fatigue (feeling of tiredness): 24 people, 18.46%
General Physical Health Deterioration (weak health status): 24 people, 18.46%
Arrhythmias (irregular heartbeat): 24 people, 18.46%
Diarrhea: 23 people, 17.69%
Weakness: 21 people, 16.15%
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 21 people, 16.15%
Acute Kidney Failure: 20 people, 15.38%

What are the existing conditions these people have? *

High Blood Pressure: 39 people, 30.00%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 19 people, 14.62%
Hyperlipidaemia (presence of excess lipids in the blood): 13 people, 10.00%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 13 people, 10.00%
Pain: 8 people, 6.15%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 8 people, 6.15%
Fever: 8 people, 6.15%
Cardiac Failure Chronic: 7 people, 5.38%
Type 1 Diabetes: 7 people, 5.38%
Bacterial Infection: 7 people, 5.38%

* Approximation only. Some reports may have incomplete information.

Do you take Rocephin and have C. diff?

- Check whether C. diff is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Rocephin:

Rocephin (15,665 reports)

C. diff treatments and more:

C. diff (13,845 reports)

Browse all side effects of Rocephin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with C. diff:

C. diff (1,570 drugs)

Browse all the conditions that are associated with C. diff:

C. diff (1,777 conditions)

Related publications that referenced our studies

Agrawal SR, Rajput A, Jain AP, "Leukocytoclastic vasculitis and acute allergic interstitial nephritis following ceftriaxone exposure", Journal of pharmacology & pharmacotherapeutics, 2014 Jan .
Agrawal SR, Rajput A, Jain AP, "Leukocytoclastic vasculitis and acute allergic interstitial nephritis following ceftriaxone exposure", Journal of pharmacology & pharmacotherapeutics, 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on ceftriaxone sodium (the active ingredients of Rocephin) and Rocephin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.