Rocephin and Hypovolaemic shock - a phase IV clinical study of FDA data

Summary:

Hypovolaemic shock is reported as a side effect among people who take Rocephin (ceftriaxone sodium), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Flagyl, and have Pain.

The phase IV clinical study analyzes which people have Hypovolaemic shock when taking Rocephin. It is created by eHealthMe based on reports of 15,458 people who have side effects when taking Rocephin from the FDA, and is updated regularly.

What is Rocephin?

Rocephin has active ingredients of ceftriaxone sodium. It is often used in infection. eHealthMe is studying from 15,665 Rocephin users. Check the latest studies of Rocephin.

What is Hypovolaemic shock?

Hypovolaemic shock (shock caused by severe blood or fluid loss) is found to be associated with 477 drugs and 592 conditions by eHealthMe. Check the latest studies of Hypovolaemic shock.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

15,458 people reported to have side effects when taking Rocephin.
Among them, 18 people (0.12%) have Hypovolaemic shock.

Could Rocephin cause Hypovolaemic shock?

Among these 18 people:

How long have people been on Rocephin when they have Hypovolaemic shock? *

What is the gender of people who have Hypovolaemic shock when taking Rocephin? *

female: 38.89 %
male: 61.11 %

What is the age of people who have Hypovolaemic shock when taking Rocephin? *

What are other drugs people take besides Rocephin? *

What are other side effects people have besides Hypovolaemic shock? *

Diarrhea: 6 people, 33.33%
Anaemia (lack of blood): 6 people, 33.33%
Hypotension (abnormally low blood pressure): 6 people, 33.33%
Septic Shock (shock due to blood infection): 5 people, 27.78%
Acute Kidney Failure: 5 people, 27.78%
Thrombocytopenia (decrease of platelets in blood): 5 people, 27.78%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 5 people, 27.78%
Melaena (the passage of black, tarry stools): 4 people, 22.22%
Nausea And Vomiting: 4 people, 22.22%
Nausea (feeling of having an urge to vomit): 4 people, 22.22%

What are the existing conditions these people have? *

Pain: 5 people, 27.78%
Nausea (feeling of having an urge to vomit): 3 people, 16.67%
Breast Cancer: 3 people, 16.67%
Breast Cancer Female: 3 people, 16.67%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 2 people, 11.11%
Depression: 2 people, 11.11%
Constipation: 2 people, 11.11%
Bacterial Infection: 2 people, 11.11%
Insomnia (sleeplessness): 2 people, 11.11%
Diarrhea: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Rocephin and have Hypovolaemic shock?

- Check whether Hypovolaemic shock is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Rocephin:

Rocephin (15,665 reports)

Browse all side effects of Rocephin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypovolaemic shock:

Hypovolaemic shock (477 drugs)

Browse all the conditions that are associated with Hypovolaemic shock:

Hypovolaemic shock (592 conditions)

Related publications that referenced our studies

Agrawal SR, Rajput A, Jain AP, "Leukocytoclastic vasculitis and acute allergic interstitial nephritis following ceftriaxone exposure", Journal of pharmacology & pharmacotherapeutics, 2014 Jan .
Agrawal SR, Rajput A, Jain AP, "Leukocytoclastic vasculitis and acute allergic interstitial nephritis following ceftriaxone exposure", Journal of pharmacology & pharmacotherapeutics, 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on ceftriaxone sodium (the active ingredients of Rocephin) and Rocephin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.