Rocephin and Lyme disease - a phase IV clinical study of FDA data

Summary:

Lyme disease is reported as a side effect among people who take Rocephin (ceftriaxone sodium), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Nuvigil, and have Narcolepsy.

The phase IV clinical study analyzes which people have Lyme disease when taking Rocephin. It is created by eHealthMe based on reports of 15,458 people who have side effects when taking Rocephin from the FDA, and is updated regularly.

What is Rocephin?

Rocephin has active ingredients of ceftriaxone sodium. It is often used in infection. eHealthMe is studying from 15,665 Rocephin users. Check the latest studies of Rocephin.

What is Lyme disease?

Lyme disease (a bacterial infection that is spread to humans by infected ticks) is found to be associated with 430 drugs and 620 conditions by eHealthMe. Check the latest studies of Lyme disease.

On Aug, 05, 2026

15,458 people reported to have side effects when taking Rocephin.
Among them, 17 people (0.11%) have Lyme disease.

Among these 17 people:

How long have people been on Rocephin when they have Lyme disease? *

What is the gender of people who have Lyme disease when taking Rocephin? *

female: 76.47 %
male: 23.53 %

What is the age of people who have Lyme disease when taking Rocephin? *

What are other drugs people take besides Rocephin? *

What are other side effects people have besides Lyme disease? *

Pain: 8 people, 47.06%
Fatigue (feeling of tiredness): 7 people, 41.18%
Tinnitus (a ringing in the ears): 6 people, 35.29%
Nausea (feeling of having an urge to vomit): 5 people, 29.41%
Stress And Anxiety: 4 people, 23.53%
Demyelination (loss of the myelin covering of some nerve fibres resulting in their impaired function): 4 people, 23.53%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 3 people, 17.65%
Back Pain: 3 people, 17.65%
Pain In Extremity: 3 people, 17.65%
Neuropathy Peripheral (surface nerve damage): 3 people, 17.65%

What are the existing conditions these people have? *

Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 35.29%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 35.29%
Pain: 3 people, 17.65%
High Blood Cholesterol: 2 people, 11.76%
Migraine (headache): 2 people, 11.76%
Complex Regional Pain Syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet)): 2 people, 11.76%
Drowsiness: 2 people, 11.76%
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain): 1 person, 5.88%
Borrelia Infection (infectious disease caused by bacteria belonging to the genus borrelia): 1 person, 5.88%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Rocephin and have Lyme disease?

- Check whether Lyme disease is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Rocephin:

Rocephin (15,665 reports)

Lyme disease treatments and more:

Lyme disease (6,358 reports)

Browse all side effects of Rocephin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Lyme disease:

Lyme disease (430 drugs)

Browse all the conditions that are associated with Lyme disease:

Lyme disease (620 conditions)

Related publications that referenced our studies

Agrawal SR, Rajput A, Jain AP, "Leukocytoclastic vasculitis and acute allergic interstitial nephritis following ceftriaxone exposure", Journal of pharmacology & pharmacotherapeutics, 2014 Jan .
Agrawal SR, Rajput A, Jain AP, "Leukocytoclastic vasculitis and acute allergic interstitial nephritis following ceftriaxone exposure", Journal of pharmacology & pharmacotherapeutics, 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on ceftriaxone sodium (the active ingredients of Rocephin) and Rocephin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.