Rybelsus and Hypotension - a phase IV clinical study of FDA data

Summary:

Hypotension is reported as a side effect among people who take Rybelsus (semaglutide), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Metformin, and have Type 2 diabetes.

The phase IV clinical study analyzes which people have Hypotension when taking Rybelsus. It is created by eHealthMe based on reports of 4,111 people who have side effects when taking Rybelsus from the FDA, and is updated regularly.

What is Rybelsus?

Rybelsus has active ingredients of semaglutide. eHealthMe is studying from 4,159 Rybelsus users. Check the latest studies of Rybelsus.

What is Hypotension?

Hypotension (abnormally low blood pressure) is found to be associated with 3,355 drugs and 4,756 conditions by eHealthMe. Check the latest studies of Hypotension.

On Jul, 23, 2026

4,111 people reported to have side effects when taking Rybelsus.
Among them, 47 people (1.14%) have Hypotension.

Among these 47 people:

How long have people been on Rybelsus when they have Hypotension? *

What is the gender of people who have Hypotension when taking Rybelsus? *

female: 43.48 %
male: 56.52 %

What is the age of people who have Hypotension when taking Rybelsus? *

What are other drugs people take besides Rybelsus? *

What are other side effects people have besides Hypotension? *

Nausea (feeling of having an urge to vomit): 9 people, 19.15%
Weight Decreased: 7 people, 14.89%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 6 people, 12.77%
Diarrhea: 5 people, 10.64%
Heart Rate Decreased: 5 people, 10.64%
Dizziness: 5 people, 10.64%
Dyspnea (difficult or laboured breathing): 5 people, 10.64%
Stress And Anxiety: 4 people, 8.51%
Dehydration (dryness resulting from the removal of water): 4 people, 8.51%
Malaise (a feeling of general discomfort or uneasiness): 4 people, 8.51%

What are the existing conditions these people have? *

Type 2 Diabetes: 21 people, 44.68%
High Blood Pressure: 8 people, 17.02%
Diabetes: 5 people, 10.64%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 6.38%
Multiple Myeloma (cancer of the plasma cells): 2 people, 4.26%
Weight Loss: 1 person, 2.13%
Ankylosing Spondylitis (type of arthritis affecting the spine): 1 person, 2.13%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 2.13%
Blood Glucose Increased: 1 person, 2.13%
Breast Cancer Female: 1 person, 2.13%

* Approximation only. Some reports may have incomplete information.

Do you take Rybelsus and have Hypotension?

- Check whether Hypotension is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Rybelsus:

Rybelsus (4,159 reports)

Hypotension treatments and more:

Hypotension (329,856 reports)

Browse all side effects of Rybelsus:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypotension:

Hypotension (3,355 drugs)

Browse all the conditions that are associated with Hypotension:

Hypotension (4,756 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on semaglutide (the active ingredients of Rybelsus) and Rybelsus (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.