Rytary and Joint swelling - a phase IV clinical study of FDA data

Summary:

Joint swelling is reported as a side effect among people who take Rytary (carbidopa; levodopa), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Nuplazid, and have Parkinson's disease.

The phase IV clinical study analyzes which people have Joint swelling when taking Rytary. It is created by eHealthMe based on reports of 17,236 people who have side effects when taking Rytary from the FDA, and is updated regularly.

What is Rytary?

Rytary has active ingredients of carbidopa; levodopa. eHealthMe is studying from 17,270 Rytary users. Check the latest studies of Rytary.

What is Joint swelling?

Joint swelling is found to be associated with 2,120 drugs and 2,938 conditions by eHealthMe. Check the latest studies of Joint swelling.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

17,236 people reported to have side effects when taking Rytary.
Among them, 61 people (0.35%) have Joint swelling.

Among these 61 people:

How long have people been on Rytary when they have Joint swelling? *

What is the gender of people who have Joint swelling when taking Rytary? *

female: 50.88 %
male: 49.12 %

What is the age of people who have Joint swelling when taking Rytary? *

What are other drugs people take besides Rytary? *

What are other side effects people have besides Joint swelling? *

Peripheral Swelling: 24 people, 39.34%
Hallucinations (sensations that appear real but are created by your mind): 10 people, 16.39%
Fall: 8 people, 13.11%
Constipation: 7 people, 11.48%
Parkinson's Disease: 7 people, 11.48%
Joint Stiffness: 6 people, 9.84%
Dyspnea (difficult or laboured breathing): 6 people, 9.84%
Freezing Phenomenon: 6 people, 9.84%
Dyskinesia (abnormality or impairment of voluntary movement): 6 people, 9.84%
Feeling Abnormal: 6 people, 9.84%

What are the existing conditions these people have? *

Parkinson's Disease: 46 people, 75.41%
Delusion (a false belief or opinion): 8 people, 13.11%
Hallucinations (sensations that appear real but are created by your mind): 8 people, 13.11%
High Blood Cholesterol: 6 people, 9.84%
High Blood Pressure: 6 people, 9.84%
On And Off Phenomenon: 4 people, 6.56%
Sleep Disorder: 3 people, 4.92%
Restless Leg Syndrome (a powerful urge to move your legs): 2 people, 3.28%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 3.28%
Heart Disease: 2 people, 3.28%

* Approximation only. Some reports may have incomplete information.

Do you take Rytary and have Joint swelling?

- Check whether Joint swelling is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Rytary:

Rytary (17,270 reports)

Joint swelling treatments and more:

Joint swelling (143,797 reports)

Browse all side effects of Rytary:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Joint swelling:

Joint swelling (2,120 drugs)

Browse all the conditions that are associated with Joint swelling:

Joint swelling (2,938 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on carbidopa; levodopa (the active ingredients of Rytary) and Rytary (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.