Sam-e and Apprehension - a phase IV clinical study of FDA data

Summary:

Apprehension is reported as a side effect among people who take Sam-e (same), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Vitamin D3, and have Cataplexy.

The phase IV clinical study analyzes which people have Apprehension when taking Sam-e. It is created by eHealthMe based on reports of 156 people who have side effects when taking Sam-e from the FDA, and is updated regularly.

What is Sam-e?

Sam-e has active ingredients of same. It is often used in depression. eHealthMe is studying from 273 Sam-e users. Check the latest studies of Sam-e.

What is Apprehension?

Apprehension is found to be associated with 4,651 drugs and 5,615 conditions by eHealthMe. Check the latest studies of Apprehension.

On Jun, 18, 2026

156 people reported to have side effects when taking Sam-e.
Among them, 11 people (7.05%) have Apprehension.

Among these 11 people:

How long have people been on Sam-e when they have Apprehension? *

What is the gender of people who have Apprehension when taking Sam-e? *

female: 81.82 %
male: 18.18 %

What is the age of people who have Apprehension when taking Sam-e? *

What are other drugs people take besides Sam-e? *

What are other side effects people have besides Apprehension? *

Heart Palpitations (feelings or sensations that your heart is pounding or racing): 5 people, 45.45%
Dizziness: 3 people, 27.27%
Migraine (headache): 2 people, 18.18%
Fatigue (feeling of tiredness): 2 people, 18.18%
Pain: 2 people, 18.18%
Feeling Abnormal: 2 people, 18.18%
Nausea (feeling of having an urge to vomit): 2 people, 18.18%
Fall: 2 people, 18.18%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 2 people, 18.18%
High Blood Pressure: 2 people, 18.18%

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 45.45%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 45.45%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 1 person, 9.09%
Prostatomegaly (enlargement of the prostate): 1 person, 9.09%
Pain: 1 person, 9.09%
Multiple Allergies (allergy to multiple agents): 1 person, 9.09%
Lambert-Eaton Syndrome (this means your immune system mistakenly targets healthy cells and tissues in the body): 1 person, 9.09%
Inflammatory Bowel Disease: 1 person, 9.09%
Hepatitis C: 1 person, 9.09%
Erection Problems: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Sam-e and have Apprehension?

- Check whether Apprehension is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Sam-e:

Sam-e (273 reports)

Apprehension treatments and more:

Apprehension (637,426 reports)

Browse all side effects of Sam-e:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Apprehension:

Apprehension (4,651 drugs)

Browse all the conditions that are associated with Apprehension:

Apprehension (5,615 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on same (the active ingredients of Sam-e) and Sam-e (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.