Sam-e and Poikiloderma - a phase IV clinical study of FDA data

Summary:

We study 401 people who take Sam-e (same) or have Poikiloderma. No report of Poikiloderma is found in people who take Sam-e.

The phase IV clinical study is created by eHealthMe based on reports from the FDA, and is updated regularly.

What is Sam-e?

Sam-e has active ingredients of same. It is often used in depression. eHealthMe is studying from 273 Sam-e users. Check the latest studies of Sam-e.

What is Poikiloderma?

Poikiloderma (pigmentary and atrophic changes in the skin) is found to be associated with 37 drugs and 42 conditions by eHealthMe. Check the latest studies of Poikiloderma.

On Jun, 18, 2026

No report is found.

Do you take Sam-e and have Poikiloderma?

- Check whether Poikiloderma is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Sam-e:

Sam-e (273 reports)

Poikiloderma treatments and more:

Poikiloderma (128 reports)

How severe was Poikiloderma and when was it recovered:

Poikiloderma in Sam-e

Expand to all the drugs that have ingredients of same:

Poikiloderma and drugs with ingredients of same

Browse all side effects of Sam-e:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Poikiloderma:

Poikiloderma

Browse all the conditions that are associated with Poikiloderma:

Poikiloderma

How the study uses the data?

The study uses data from the FDA. It is based on same (the active ingredients of Sam-e) and Sam-e (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.