Samsca and Nasal congestion - a phase IV clinical study of FDA data

Summary:

Nasal congestion is reported as a side effect among people who take Samsca (tolvaptan), especially for people who are female, 40-49 old, have been taking the drug for 2 - 5 years also take Lasix, and have Primary pulmonary hypertension.

The phase IV clinical study analyzes which people have Nasal congestion when taking Samsca. It is created by eHealthMe based on reports of 8,134 people who have side effects when taking Samsca from the FDA, and is updated regularly.

What is Samsca?

Samsca has active ingredients of tolvaptan. eHealthMe is studying from 8,139 Samsca users. Check the latest studies of Samsca.

What is Nasal congestion?

Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels) is found to be associated with 1,763 drugs and 2,490 conditions by eHealthMe. Check the latest studies of Nasal congestion.

On Apr, 26, 2026

8,134 people reported to have side effects when taking Samsca.
Among them, 13 people (0.16%) have Nasal congestion.

Among these 13 people:

How long have people been on Samsca when they have Nasal congestion? *

What is the gender of people who have Nasal congestion when taking Samsca? *

female: 100 %
male: 0.0 %

What is the age of people who have Nasal congestion when taking Samsca? *

What are other drugs people take besides Samsca? *

What are other side effects people have besides Nasal congestion? *

Headache (pain in head): 7 people, 53.85%
Cough: 6 people, 46.15%
Nausea (feeling of having an urge to vomit): 5 people, 38.46%
Anaemia (lack of blood): 5 people, 38.46%
Bradycardia (abnormally slow heart action): 5 people, 38.46%
Oedema (fluid collection in tissue): 5 people, 38.46%
Right Ventricular Failure (right half of the heart fails to work): 5 people, 38.46%
Diarrhea: 5 people, 38.46%
Fever: 5 people, 38.46%
Joint Pain: 5 people, 38.46%

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 10 people, 76.92%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 5 people, 38.46%
Type 1 Diabetes: 3 people, 23.08%
Right Ventricular Failure (right half of the heart fails to work): 3 people, 23.08%
Pulmonary Embolism (blockage of the main artery of the lung): 3 people, 23.08%
Insomnia (sleeplessness): 2 people, 15.38%
Cardiac Failure: 2 people, 15.38%
Diabetes: 2 people, 15.38%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 2 people, 15.38%
Gastritis (inflammation of stomach): 2 people, 15.38%

* Approximation only. Some reports may have incomplete information.

Do you take Samsca and have Nasal congestion?

- Check whether Nasal congestion is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Samsca:

Samsca (8,139 reports)

Nasal congestion treatments and more:

Nasal congestion (81,823 reports)

Browse all side effects of Samsca:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Nasal congestion:

Nasal congestion (1,763 drugs)

Browse all the conditions that are associated with Nasal congestion:

Nasal congestion (2,490 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on tolvaptan (the active ingredients of Samsca) and Samsca (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.